Crystal Structures of Fsa2 and Phm7 Catalyzing [4 + 2] Cycloaddition Reactions with Reverse Stereoselectivities in Equisetin and Phomasetin Biosynthesis

[Image: see text] Fsa2 and Phm7 are a unique pair of pericyclases catalyzing [4 + 2] cycloaddition reactions with reverse stereoselectivities in the biosynthesis of equisetin and phomasetin, both of which are potent HIV-1 integrase inhibitors. We here solve the crystal structures of Fsa2 and Phm7, b...

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Detalles Bibliográficos
Autores principales: Chi, Changbiao, Wang, Zhengdong, Liu, Tan, Zhang, Zhongyi, Zhou, Huan, Li, Annan, Jin, Hongwei, Jia, Hongli, Yin, Fuling, Yang, Donghui, Ma, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154222/
https://www.ncbi.nlm.nih.gov/pubmed/34056443
http://dx.doi.org/10.1021/acsomega.1c01593

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