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Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors

[Image: see text] Ketamine is an anesthetic, analgesic, and antidepressant whose secondary metabolite (2R,6R)-hydroxynorketamine (HNK) has N-methyl-d-aspartate-receptor-independent antidepressant activity in a rodent model. In humans, naltrexone attenuates its antidepressant effect, consistent with...

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Detalles Bibliográficos
Autores principales:	Joseph, Thomas T., Bu, Weiming, Lin, Wenzhen, Zoubak, Lioudmila, Yeliseev, Alexei, Liu, Renyu, Eckenhoff, Roderic G., Brannigan, Grace
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154314/ https://www.ncbi.nlm.nih.gov/pubmed/33905229 http://dx.doi.org/10.1021/acschemneuro.0c00741

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