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Geographic Distribution of Cytomegalovirus Serology in Kidney and Pancreas Transplant Recipients in the United States
BACKGROUNDS. Cytomegalovirus (CMV) negatively affects transplant outcomes. The current geographic distribution of CMV risk within the US has not been described. METHODS. CMV serostatus of donors and recipients in each US state were collected from the Scientific Registry of Transplant Recipients betw...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154463/ https://www.ncbi.nlm.nih.gov/pubmed/34056079 http://dx.doi.org/10.1097/TXD.0000000000001147 |
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author | Jorgenson, Margaret R. Parajuli, Sandesh Marka, Nicholas Leverson, Glen E. Smith, Jeannina A. Mandelbrot, Didier A. Odorico, Jon S. |
author_facet | Jorgenson, Margaret R. Parajuli, Sandesh Marka, Nicholas Leverson, Glen E. Smith, Jeannina A. Mandelbrot, Didier A. Odorico, Jon S. |
author_sort | Jorgenson, Margaret R. |
collection | PubMed |
description | BACKGROUNDS. Cytomegalovirus (CMV) negatively affects transplant outcomes. The current geographic distribution of CMV risk within the US has not been described. METHODS. CMV serostatus of donors and recipients in each US state were collected from the Scientific Registry of Transplant Recipients between April 1, 2015, and March 31, 2019. The objective was to describe rates of CMV recipient seropositivity (R+) and high-risk serostatus (D+/R−) across the US in kidney transplant recipient (KTR) and pancreas transplant recipient (PTR) and explore geographic disparities. RESULTS. A total of 79 276 KTRs and 4023 PTRs were included. The average KTR R+ rate across states was 59.5% (range 39%–76%); PTR R+ rate was 49.5% but with a broader range (0%–100%). The average KTR D+/R− rate across the US was 19% (range 8.7%–25%); PTR D+/R− rate was notably higher (26.9%, range 0%–50%). KTR seropositivity varied geographically with more R+ recipients in the southern states, Alaska, and Hawaii. D+/R− KTRs also varied by region, with higher rates in the Rocky Mountain Region as well as the Midwest and the northern-most states of the Northeast. Trends found in KTR persisted in PTR. CONCLUSIONS. The distribution of CMV serostatus in the US varies by state and allograft type. These data may be useful in further discussion of national CMV donor-matching strategies. |
format | Online Article Text |
id | pubmed-8154463 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-81544632021-05-28 Geographic Distribution of Cytomegalovirus Serology in Kidney and Pancreas Transplant Recipients in the United States Jorgenson, Margaret R. Parajuli, Sandesh Marka, Nicholas Leverson, Glen E. Smith, Jeannina A. Mandelbrot, Didier A. Odorico, Jon S. Transplant Direct Infectious Disease BACKGROUNDS. Cytomegalovirus (CMV) negatively affects transplant outcomes. The current geographic distribution of CMV risk within the US has not been described. METHODS. CMV serostatus of donors and recipients in each US state were collected from the Scientific Registry of Transplant Recipients between April 1, 2015, and March 31, 2019. The objective was to describe rates of CMV recipient seropositivity (R+) and high-risk serostatus (D+/R−) across the US in kidney transplant recipient (KTR) and pancreas transplant recipient (PTR) and explore geographic disparities. RESULTS. A total of 79 276 KTRs and 4023 PTRs were included. The average KTR R+ rate across states was 59.5% (range 39%–76%); PTR R+ rate was 49.5% but with a broader range (0%–100%). The average KTR D+/R− rate across the US was 19% (range 8.7%–25%); PTR D+/R− rate was notably higher (26.9%, range 0%–50%). KTR seropositivity varied geographically with more R+ recipients in the southern states, Alaska, and Hawaii. D+/R− KTRs also varied by region, with higher rates in the Rocky Mountain Region as well as the Midwest and the northern-most states of the Northeast. Trends found in KTR persisted in PTR. CONCLUSIONS. The distribution of CMV serostatus in the US varies by state and allograft type. These data may be useful in further discussion of national CMV donor-matching strategies. Lippincott Williams & Wilkins 2021-05-25 /pmc/articles/PMC8154463/ /pubmed/34056079 http://dx.doi.org/10.1097/TXD.0000000000001147 Text en Copyright © 2021 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Infectious Disease Jorgenson, Margaret R. Parajuli, Sandesh Marka, Nicholas Leverson, Glen E. Smith, Jeannina A. Mandelbrot, Didier A. Odorico, Jon S. Geographic Distribution of Cytomegalovirus Serology in Kidney and Pancreas Transplant Recipients in the United States |
title | Geographic Distribution of Cytomegalovirus Serology in Kidney and Pancreas Transplant Recipients in the United States |
title_full | Geographic Distribution of Cytomegalovirus Serology in Kidney and Pancreas Transplant Recipients in the United States |
title_fullStr | Geographic Distribution of Cytomegalovirus Serology in Kidney and Pancreas Transplant Recipients in the United States |
title_full_unstemmed | Geographic Distribution of Cytomegalovirus Serology in Kidney and Pancreas Transplant Recipients in the United States |
title_short | Geographic Distribution of Cytomegalovirus Serology in Kidney and Pancreas Transplant Recipients in the United States |
title_sort | geographic distribution of cytomegalovirus serology in kidney and pancreas transplant recipients in the united states |
topic | Infectious Disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154463/ https://www.ncbi.nlm.nih.gov/pubmed/34056079 http://dx.doi.org/10.1097/TXD.0000000000001147 |
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