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Long-term response on letrozole for gastric cancer: A case report
RATIONALE: Hormone therapies, particularly those targeting estrogen and its receptors, are a key treatment modality for patients with estrogen receptor (ER)-positive breast or ovarian cancer. Some gastric cancers (GCs) express ERs, and preclinical studies suggest the potential of estrogen-targeting...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154479/ https://www.ncbi.nlm.nih.gov/pubmed/34032767 http://dx.doi.org/10.1097/MD.0000000000026146 |
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author | Iida, Yuuki Hongo, Kumiko Onoda, Takanobu Kita, Yusuke Ishihara, Yukio Takabayashi, Naoki Kobayashi, Ryo Kuriki, Ken Hiramatsu, Takeyuki |
author_facet | Iida, Yuuki Hongo, Kumiko Onoda, Takanobu Kita, Yusuke Ishihara, Yukio Takabayashi, Naoki Kobayashi, Ryo Kuriki, Ken Hiramatsu, Takeyuki |
author_sort | Iida, Yuuki |
collection | PubMed |
description | RATIONALE: Hormone therapies, particularly those targeting estrogen and its receptors, are a key treatment modality for patients with estrogen receptor (ER)-positive breast or ovarian cancer. Some gastric cancers (GCs) express ERs, and preclinical studies suggest the potential of estrogen-targeting hormone therapy on GC; however, the clinical relevance of this hormone therapy on GC treatment has not been well elucidated. PATIENT CONCERNS: An 80-year-old female was admitted to our department with hypogastric pain and vomiting. Computed tomography demonstrated small bowel obstruction, and laparotomy after bowel decompression revealed peritoneal dissemination consisting of a poorly-differentiated adenocarcinoma. Intestinal bypass between the ileum and transverse colon was performed. DIAGNOSES: The tumor was ER- and mammaglobin-positive, indicating that it originated from a breast cancer. Diagnostic imaging revealed no evidence of breast cancer; however, right axillary ER- and mammaglobin-positive lymphadenopathy was found. INTERVENTIONS: The patient received hormone therapy using letrozole based on a clinical diagnosis of occult breast cancer with peritoneal dissemination and right axillary lymph node metastasis. OUTCOMES: The patient remained disease free until 37 months but deceased at 53 months from the onset of disease. An autopsy revealed no tumor cells in the right breast tissue; however, there was a massive invasion of cancer cells in the stomach. LESSONS: A patient with ER positive GC with peritoneal dissemination and right axillary lymph node metastasis presented remarkable response to letrozole. The long-term survival obtained using letrozole for a patient with GC with distant metastasis suggests the potential of estrogen targeting hormone therapies for GC. |
format | Online Article Text |
id | pubmed-8154479 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-81544792021-05-29 Long-term response on letrozole for gastric cancer: A case report Iida, Yuuki Hongo, Kumiko Onoda, Takanobu Kita, Yusuke Ishihara, Yukio Takabayashi, Naoki Kobayashi, Ryo Kuriki, Ken Hiramatsu, Takeyuki Medicine (Baltimore) 4500 RATIONALE: Hormone therapies, particularly those targeting estrogen and its receptors, are a key treatment modality for patients with estrogen receptor (ER)-positive breast or ovarian cancer. Some gastric cancers (GCs) express ERs, and preclinical studies suggest the potential of estrogen-targeting hormone therapy on GC; however, the clinical relevance of this hormone therapy on GC treatment has not been well elucidated. PATIENT CONCERNS: An 80-year-old female was admitted to our department with hypogastric pain and vomiting. Computed tomography demonstrated small bowel obstruction, and laparotomy after bowel decompression revealed peritoneal dissemination consisting of a poorly-differentiated adenocarcinoma. Intestinal bypass between the ileum and transverse colon was performed. DIAGNOSES: The tumor was ER- and mammaglobin-positive, indicating that it originated from a breast cancer. Diagnostic imaging revealed no evidence of breast cancer; however, right axillary ER- and mammaglobin-positive lymphadenopathy was found. INTERVENTIONS: The patient received hormone therapy using letrozole based on a clinical diagnosis of occult breast cancer with peritoneal dissemination and right axillary lymph node metastasis. OUTCOMES: The patient remained disease free until 37 months but deceased at 53 months from the onset of disease. An autopsy revealed no tumor cells in the right breast tissue; however, there was a massive invasion of cancer cells in the stomach. LESSONS: A patient with ER positive GC with peritoneal dissemination and right axillary lymph node metastasis presented remarkable response to letrozole. The long-term survival obtained using letrozole for a patient with GC with distant metastasis suggests the potential of estrogen targeting hormone therapies for GC. Lippincott Williams & Wilkins 2021-05-28 /pmc/articles/PMC8154479/ /pubmed/34032767 http://dx.doi.org/10.1097/MD.0000000000026146 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | 4500 Iida, Yuuki Hongo, Kumiko Onoda, Takanobu Kita, Yusuke Ishihara, Yukio Takabayashi, Naoki Kobayashi, Ryo Kuriki, Ken Hiramatsu, Takeyuki Long-term response on letrozole for gastric cancer: A case report |
title | Long-term response on letrozole for gastric cancer: A case report |
title_full | Long-term response on letrozole for gastric cancer: A case report |
title_fullStr | Long-term response on letrozole for gastric cancer: A case report |
title_full_unstemmed | Long-term response on letrozole for gastric cancer: A case report |
title_short | Long-term response on letrozole for gastric cancer: A case report |
title_sort | long-term response on letrozole for gastric cancer: a case report |
topic | 4500 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154479/ https://www.ncbi.nlm.nih.gov/pubmed/34032767 http://dx.doi.org/10.1097/MD.0000000000026146 |
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