Cargando…

Long-term response on letrozole for gastric cancer: A case report

RATIONALE: Hormone therapies, particularly those targeting estrogen and its receptors, are a key treatment modality for patients with estrogen receptor (ER)-positive breast or ovarian cancer. Some gastric cancers (GCs) express ERs, and preclinical studies suggest the potential of estrogen-targeting...

Descripción completa

Detalles Bibliográficos
Autores principales: Iida, Yuuki, Hongo, Kumiko, Onoda, Takanobu, Kita, Yusuke, Ishihara, Yukio, Takabayashi, Naoki, Kobayashi, Ryo, Kuriki, Ken, Hiramatsu, Takeyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154479/
https://www.ncbi.nlm.nih.gov/pubmed/34032767
http://dx.doi.org/10.1097/MD.0000000000026146
_version_ 1783699023630172160
author Iida, Yuuki
Hongo, Kumiko
Onoda, Takanobu
Kita, Yusuke
Ishihara, Yukio
Takabayashi, Naoki
Kobayashi, Ryo
Kuriki, Ken
Hiramatsu, Takeyuki
author_facet Iida, Yuuki
Hongo, Kumiko
Onoda, Takanobu
Kita, Yusuke
Ishihara, Yukio
Takabayashi, Naoki
Kobayashi, Ryo
Kuriki, Ken
Hiramatsu, Takeyuki
author_sort Iida, Yuuki
collection PubMed
description RATIONALE: Hormone therapies, particularly those targeting estrogen and its receptors, are a key treatment modality for patients with estrogen receptor (ER)-positive breast or ovarian cancer. Some gastric cancers (GCs) express ERs, and preclinical studies suggest the potential of estrogen-targeting hormone therapy on GC; however, the clinical relevance of this hormone therapy on GC treatment has not been well elucidated. PATIENT CONCERNS: An 80-year-old female was admitted to our department with hypogastric pain and vomiting. Computed tomography demonstrated small bowel obstruction, and laparotomy after bowel decompression revealed peritoneal dissemination consisting of a poorly-differentiated adenocarcinoma. Intestinal bypass between the ileum and transverse colon was performed. DIAGNOSES: The tumor was ER- and mammaglobin-positive, indicating that it originated from a breast cancer. Diagnostic imaging revealed no evidence of breast cancer; however, right axillary ER- and mammaglobin-positive lymphadenopathy was found. INTERVENTIONS: The patient received hormone therapy using letrozole based on a clinical diagnosis of occult breast cancer with peritoneal dissemination and right axillary lymph node metastasis. OUTCOMES: The patient remained disease free until 37 months but deceased at 53 months from the onset of disease. An autopsy revealed no tumor cells in the right breast tissue; however, there was a massive invasion of cancer cells in the stomach. LESSONS: A patient with ER positive GC with peritoneal dissemination and right axillary lymph node metastasis presented remarkable response to letrozole. The long-term survival obtained using letrozole for a patient with GC with distant metastasis suggests the potential of estrogen targeting hormone therapies for GC.
format Online
Article
Text
id pubmed-8154479
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-81544792021-05-29 Long-term response on letrozole for gastric cancer: A case report Iida, Yuuki Hongo, Kumiko Onoda, Takanobu Kita, Yusuke Ishihara, Yukio Takabayashi, Naoki Kobayashi, Ryo Kuriki, Ken Hiramatsu, Takeyuki Medicine (Baltimore) 4500 RATIONALE: Hormone therapies, particularly those targeting estrogen and its receptors, are a key treatment modality for patients with estrogen receptor (ER)-positive breast or ovarian cancer. Some gastric cancers (GCs) express ERs, and preclinical studies suggest the potential of estrogen-targeting hormone therapy on GC; however, the clinical relevance of this hormone therapy on GC treatment has not been well elucidated. PATIENT CONCERNS: An 80-year-old female was admitted to our department with hypogastric pain and vomiting. Computed tomography demonstrated small bowel obstruction, and laparotomy after bowel decompression revealed peritoneal dissemination consisting of a poorly-differentiated adenocarcinoma. Intestinal bypass between the ileum and transverse colon was performed. DIAGNOSES: The tumor was ER- and mammaglobin-positive, indicating that it originated from a breast cancer. Diagnostic imaging revealed no evidence of breast cancer; however, right axillary ER- and mammaglobin-positive lymphadenopathy was found. INTERVENTIONS: The patient received hormone therapy using letrozole based on a clinical diagnosis of occult breast cancer with peritoneal dissemination and right axillary lymph node metastasis. OUTCOMES: The patient remained disease free until 37 months but deceased at 53 months from the onset of disease. An autopsy revealed no tumor cells in the right breast tissue; however, there was a massive invasion of cancer cells in the stomach. LESSONS: A patient with ER positive GC with peritoneal dissemination and right axillary lymph node metastasis presented remarkable response to letrozole. The long-term survival obtained using letrozole for a patient with GC with distant metastasis suggests the potential of estrogen targeting hormone therapies for GC. Lippincott Williams & Wilkins 2021-05-28 /pmc/articles/PMC8154479/ /pubmed/34032767 http://dx.doi.org/10.1097/MD.0000000000026146 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 4500
Iida, Yuuki
Hongo, Kumiko
Onoda, Takanobu
Kita, Yusuke
Ishihara, Yukio
Takabayashi, Naoki
Kobayashi, Ryo
Kuriki, Ken
Hiramatsu, Takeyuki
Long-term response on letrozole for gastric cancer: A case report
title Long-term response on letrozole for gastric cancer: A case report
title_full Long-term response on letrozole for gastric cancer: A case report
title_fullStr Long-term response on letrozole for gastric cancer: A case report
title_full_unstemmed Long-term response on letrozole for gastric cancer: A case report
title_short Long-term response on letrozole for gastric cancer: A case report
title_sort long-term response on letrozole for gastric cancer: a case report
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154479/
https://www.ncbi.nlm.nih.gov/pubmed/34032767
http://dx.doi.org/10.1097/MD.0000000000026146
work_keys_str_mv AT iidayuuki longtermresponseonletrozoleforgastriccanceracasereport
AT hongokumiko longtermresponseonletrozoleforgastriccanceracasereport
AT onodatakanobu longtermresponseonletrozoleforgastriccanceracasereport
AT kitayusuke longtermresponseonletrozoleforgastriccanceracasereport
AT ishiharayukio longtermresponseonletrozoleforgastriccanceracasereport
AT takabayashinaoki longtermresponseonletrozoleforgastriccanceracasereport
AT kobayashiryo longtermresponseonletrozoleforgastriccanceracasereport
AT kurikiken longtermresponseonletrozoleforgastriccanceracasereport
AT hiramatsutakeyuki longtermresponseonletrozoleforgastriccanceracasereport