Protein C Gene Mutation in an Older Adult Patient with Clostridium perfringens Septicemia-Related Visceral Vein Thrombosis

A 78-year-old Japanese male with Clostridium perfringens septicemia and cholecystitis was found to have thrombosis in the left branch of intrahepatic portal vein as well as superior mesenteric vein. Visceral vein thrombosis (VVT) in this case was associated with protein C deficiency, due to a hetero...

Descripción completa

Detalles Bibliográficos
Autores principales: Kanosue, Kiyoko, Nagaya, Satomi, Morishita, Eriko, Yamanishi, Masayoshi, Imashuku, Shinsaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154515/
https://www.ncbi.nlm.nih.gov/pubmed/34056524
http://dx.doi.org/10.1055/s-0041-1728664
_version_ 1783699032383684608
author Kanosue, Kiyoko
Nagaya, Satomi
Morishita, Eriko
Yamanishi, Masayoshi
Imashuku, Shinsaku
author_facet Kanosue, Kiyoko
Nagaya, Satomi
Morishita, Eriko
Yamanishi, Masayoshi
Imashuku, Shinsaku
author_sort Kanosue, Kiyoko
collection PubMed
description A 78-year-old Japanese male with Clostridium perfringens septicemia and cholecystitis was found to have thrombosis in the left branch of intrahepatic portal vein as well as superior mesenteric vein. Visceral vein thrombosis (VVT) in this case was associated with protein C deficiency, due to a heterozygous mutation, p. Arg185Met. Our experience emphasizes that VVT, or other thromboembolic events, may occur in later life, triggered by environmental thrombosis risk factors, together with underlying hereditary protein C gene mutation.
format Online
Article
Text
id pubmed-8154515
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Georg Thieme Verlag KG
record_format MEDLINE/PubMed
spelling pubmed-81545152021-05-28 Protein C Gene Mutation in an Older Adult Patient with Clostridium perfringens Septicemia-Related Visceral Vein Thrombosis Kanosue, Kiyoko Nagaya, Satomi Morishita, Eriko Yamanishi, Masayoshi Imashuku, Shinsaku TH Open A 78-year-old Japanese male with Clostridium perfringens septicemia and cholecystitis was found to have thrombosis in the left branch of intrahepatic portal vein as well as superior mesenteric vein. Visceral vein thrombosis (VVT) in this case was associated with protein C deficiency, due to a heterozygous mutation, p. Arg185Met. Our experience emphasizes that VVT, or other thromboembolic events, may occur in later life, triggered by environmental thrombosis risk factors, together with underlying hereditary protein C gene mutation. Georg Thieme Verlag KG 2021-05-26 /pmc/articles/PMC8154515/ /pubmed/34056524 http://dx.doi.org/10.1055/s-0041-1728664 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Kanosue, Kiyoko
Nagaya, Satomi
Morishita, Eriko
Yamanishi, Masayoshi
Imashuku, Shinsaku
Protein C Gene Mutation in an Older Adult Patient with Clostridium perfringens Septicemia-Related Visceral Vein Thrombosis
title Protein C Gene Mutation in an Older Adult Patient with Clostridium perfringens Septicemia-Related Visceral Vein Thrombosis
title_full Protein C Gene Mutation in an Older Adult Patient with Clostridium perfringens Septicemia-Related Visceral Vein Thrombosis
title_fullStr Protein C Gene Mutation in an Older Adult Patient with Clostridium perfringens Septicemia-Related Visceral Vein Thrombosis
title_full_unstemmed Protein C Gene Mutation in an Older Adult Patient with Clostridium perfringens Septicemia-Related Visceral Vein Thrombosis
title_short Protein C Gene Mutation in an Older Adult Patient with Clostridium perfringens Septicemia-Related Visceral Vein Thrombosis
title_sort protein c gene mutation in an older adult patient with clostridium perfringens septicemia-related visceral vein thrombosis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154515/
https://www.ncbi.nlm.nih.gov/pubmed/34056524
http://dx.doi.org/10.1055/s-0041-1728664
work_keys_str_mv AT kanosuekiyoko proteincgenemutationinanolderadultpatientwithclostridiumperfringenssepticemiarelatedvisceralveinthrombosis
AT nagayasatomi proteincgenemutationinanolderadultpatientwithclostridiumperfringenssepticemiarelatedvisceralveinthrombosis
AT morishitaeriko proteincgenemutationinanolderadultpatientwithclostridiumperfringenssepticemiarelatedvisceralveinthrombosis
AT yamanishimasayoshi proteincgenemutationinanolderadultpatientwithclostridiumperfringenssepticemiarelatedvisceralveinthrombosis
AT imashukushinsaku proteincgenemutationinanolderadultpatientwithclostridiumperfringenssepticemiarelatedvisceralveinthrombosis

Ejemplares similares