Azine Activation via Silylium Catalysis

[Image: see text] Practical, efficient, and general methods for the diversification of N-heterocycles have been a recurrent goal in chemical synthesis due to the ubiquitous influence of these motifs within bioactive frameworks. Here, we describe a direct, catalytic, and selective functionalization o...

Descripción completa

Detalles Bibliográficos
Autores principales: Obradors, Carla, List, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154516/
https://www.ncbi.nlm.nih.gov/pubmed/33908753
http://dx.doi.org/10.1021/jacs.1c03257
_version_ 1783699032622759936
author Obradors, Carla
List, Benjamin
author_facet Obradors, Carla
List, Benjamin
author_sort Obradors, Carla
collection PubMed
description [Image: see text] Practical, efficient, and general methods for the diversification of N-heterocycles have been a recurrent goal in chemical synthesis due to the ubiquitous influence of these motifs within bioactive frameworks. Here, we describe a direct, catalytic, and selective functionalization of azines via silylium activation. Our catalyst design enables mild conditions and a remarkable functional group tolerance in a one-pot setup.
format Online
Article
Text
id pubmed-8154516
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-81545162021-05-27 Azine Activation via Silylium Catalysis Obradors, Carla List, Benjamin J Am Chem Soc [Image: see text] Practical, efficient, and general methods for the diversification of N-heterocycles have been a recurrent goal in chemical synthesis due to the ubiquitous influence of these motifs within bioactive frameworks. Here, we describe a direct, catalytic, and selective functionalization of azines via silylium activation. Our catalyst design enables mild conditions and a remarkable functional group tolerance in a one-pot setup. American Chemical Society 2021-04-28 2021-05-12 /pmc/articles/PMC8154516/ /pubmed/33908753 http://dx.doi.org/10.1021/jacs.1c03257 Text en © 2021 The Authors. Published by American Chemical Society Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Obradors, Carla
List, Benjamin
Azine Activation via Silylium Catalysis
title Azine Activation via Silylium Catalysis
title_full Azine Activation via Silylium Catalysis
title_fullStr Azine Activation via Silylium Catalysis
title_full_unstemmed Azine Activation via Silylium Catalysis
title_short Azine Activation via Silylium Catalysis
title_sort azine activation via silylium catalysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154516/
https://www.ncbi.nlm.nih.gov/pubmed/33908753
http://dx.doi.org/10.1021/jacs.1c03257
work_keys_str_mv AT obradorscarla azineactivationviasilyliumcatalysis
AT listbenjamin azineactivationviasilyliumcatalysis

Ejemplares similares