A New Ligand Design Based on London Dispersion Empowers Chiral Bismuth–Rhodium Paddlewheel Catalysts

[Image: see text] Heterobimetallic bismuth–rhodium paddlewheel complexes with phenylglycine ligands carrying TIPS-groups at the meta-positions of the aromatic ring exhibit outstanding levels of selectivity in reactions of donor/acceptor and donor/donor carbenes; at the same time, the reaction rates...

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Autores principales: Singha, Santanu, Buchsteiner, Michael, Bistoni, Giovanni, Goddard, Richard, Fürstner, Alois
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154533/
https://www.ncbi.nlm.nih.gov/pubmed/33829767
http://dx.doi.org/10.1021/jacs.1c01972
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author Singha, Santanu
Buchsteiner, Michael
Bistoni, Giovanni
Goddard, Richard
Fürstner, Alois
author_facet Singha, Santanu
Buchsteiner, Michael
Bistoni, Giovanni
Goddard, Richard
Fürstner, Alois
author_sort Singha, Santanu
collection PubMed
description [Image: see text] Heterobimetallic bismuth–rhodium paddlewheel complexes with phenylglycine ligands carrying TIPS-groups at the meta-positions of the aromatic ring exhibit outstanding levels of selectivity in reactions of donor/acceptor and donor/donor carbenes; at the same time, the reaction rates are much faster and the substrate scope is considerably wider than those of previous generations of chiral [BiRh] catalysts. As shown by a combined experimental, crystallographic, and computational study, the new catalysts draw their excellent application profile largely from the stabilization of the chiral ligand sphere by London dispersion (LD) interactions of the peripheral silyl substituents.
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spelling pubmed-81545332021-05-27 A New Ligand Design Based on London Dispersion Empowers Chiral Bismuth–Rhodium Paddlewheel Catalysts Singha, Santanu Buchsteiner, Michael Bistoni, Giovanni Goddard, Richard Fürstner, Alois J Am Chem Soc [Image: see text] Heterobimetallic bismuth–rhodium paddlewheel complexes with phenylglycine ligands carrying TIPS-groups at the meta-positions of the aromatic ring exhibit outstanding levels of selectivity in reactions of donor/acceptor and donor/donor carbenes; at the same time, the reaction rates are much faster and the substrate scope is considerably wider than those of previous generations of chiral [BiRh] catalysts. As shown by a combined experimental, crystallographic, and computational study, the new catalysts draw their excellent application profile largely from the stabilization of the chiral ligand sphere by London dispersion (LD) interactions of the peripheral silyl substituents. American Chemical Society 2021-04-08 2021-04-21 /pmc/articles/PMC8154533/ /pubmed/33829767 http://dx.doi.org/10.1021/jacs.1c01972 Text en © 2021 The Authors. Published by American Chemical Society Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Singha, Santanu
Buchsteiner, Michael
Bistoni, Giovanni
Goddard, Richard
Fürstner, Alois
A New Ligand Design Based on London Dispersion Empowers Chiral Bismuth–Rhodium Paddlewheel Catalysts
title A New Ligand Design Based on London Dispersion Empowers Chiral Bismuth–Rhodium Paddlewheel Catalysts
title_full A New Ligand Design Based on London Dispersion Empowers Chiral Bismuth–Rhodium Paddlewheel Catalysts
title_fullStr A New Ligand Design Based on London Dispersion Empowers Chiral Bismuth–Rhodium Paddlewheel Catalysts
title_full_unstemmed A New Ligand Design Based on London Dispersion Empowers Chiral Bismuth–Rhodium Paddlewheel Catalysts
title_short A New Ligand Design Based on London Dispersion Empowers Chiral Bismuth–Rhodium Paddlewheel Catalysts
title_sort new ligand design based on london dispersion empowers chiral bismuth–rhodium paddlewheel catalysts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154533/
https://www.ncbi.nlm.nih.gov/pubmed/33829767
http://dx.doi.org/10.1021/jacs.1c01972
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