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Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy

Multi-subunit ATPase-dependent chromatin remodelling complexes SWI/SNF (switch/sucrose non-fermentable) are fundamental epigenetic regulators of gene transcription. Functional genomic studies revealed a remarkable mutation prevalence of SWI/SNF-encoding genes in 20–25% of all human cancers, frequent...

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Detalles Bibliográficos
Autores principales:	Wanior, Marek, Krämer, Andreas, Knapp, Stefan, Joerger, Andreas C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154588/ https://www.ncbi.nlm.nih.gov/pubmed/33941852 http://dx.doi.org/10.1038/s41388-021-01781-x

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