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Unidirectional porous beta-tricalcium phosphate and hydroxyapatite artificial bone: a review of experimental evaluations and clinical applications

In Japan, where allograft bone transplantation is not widespread, prospects for artificial bones are very high. Therefore, artificial bones with various compositions, porous structures, and porosities have been developed and employed for clinical use. Both Affinos(®) and Regenos(®) (made of beta-tri...

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Autores principales: Funayama, Toru, Noguchi, Hiroshi, Kumagai, Hiroshi, Sato, Kosuke, Yoshioka, Tomokazu, Yamazaki, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154753/
https://www.ncbi.nlm.nih.gov/pubmed/33893573
http://dx.doi.org/10.1007/s10047-021-01270-8
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author Funayama, Toru
Noguchi, Hiroshi
Kumagai, Hiroshi
Sato, Kosuke
Yoshioka, Tomokazu
Yamazaki, Masashi
author_facet Funayama, Toru
Noguchi, Hiroshi
Kumagai, Hiroshi
Sato, Kosuke
Yoshioka, Tomokazu
Yamazaki, Masashi
author_sort Funayama, Toru
collection PubMed
description In Japan, where allograft bone transplantation is not widespread, prospects for artificial bones are very high. Therefore, artificial bones with various compositions, porous structures, and porosities have been developed and employed for clinical use. Both Affinos(®) and Regenos(®) (made of beta-tricalcium phosphate and hydroxyapatite, respectively) are artificial bones with a unique unidirectional porous structure, in which pores with a diameter suitable for tissue penetration (25–300 μm) are aligned in one direction. The unidirectional porous structure allows rapid penetration of blood deep into the materials by a capillary effect. In animal experiments, Affinos(®) showed well-balanced resorption and was replaced with the host’s own bone from an early stage after implantation and new bone formation and remodeling were observed in the cortical bone and medullary cavity. When implanted for clinical situation, resorption from an early stage and good replacement with the patient’s own bone were also observed. Regenos(®) has an internal osteon-like material and a vascular-like structure that is maintained within the pores even after long-term implantation, as noted in an animal experiment. When implanted for clinical situation, good osteoconductivity was observed from an early stage of implantation. In addition, the material was observed to be slowly absorbed over time in some cases. We have discussed the beneficial effects of combining teriparatide and platelet-rich plasma impregnation and the potential prospects of these artificial bones. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10047-021-01270-8.
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spelling pubmed-81547532021-06-01 Unidirectional porous beta-tricalcium phosphate and hydroxyapatite artificial bone: a review of experimental evaluations and clinical applications Funayama, Toru Noguchi, Hiroshi Kumagai, Hiroshi Sato, Kosuke Yoshioka, Tomokazu Yamazaki, Masashi J Artif Organs Review In Japan, where allograft bone transplantation is not widespread, prospects for artificial bones are very high. Therefore, artificial bones with various compositions, porous structures, and porosities have been developed and employed for clinical use. Both Affinos(®) and Regenos(®) (made of beta-tricalcium phosphate and hydroxyapatite, respectively) are artificial bones with a unique unidirectional porous structure, in which pores with a diameter suitable for tissue penetration (25–300 μm) are aligned in one direction. The unidirectional porous structure allows rapid penetration of blood deep into the materials by a capillary effect. In animal experiments, Affinos(®) showed well-balanced resorption and was replaced with the host’s own bone from an early stage after implantation and new bone formation and remodeling were observed in the cortical bone and medullary cavity. When implanted for clinical situation, resorption from an early stage and good replacement with the patient’s own bone were also observed. Regenos(®) has an internal osteon-like material and a vascular-like structure that is maintained within the pores even after long-term implantation, as noted in an animal experiment. When implanted for clinical situation, good osteoconductivity was observed from an early stage of implantation. In addition, the material was observed to be slowly absorbed over time in some cases. We have discussed the beneficial effects of combining teriparatide and platelet-rich plasma impregnation and the potential prospects of these artificial bones. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10047-021-01270-8. Springer Japan 2021-04-23 2021 /pmc/articles/PMC8154753/ /pubmed/33893573 http://dx.doi.org/10.1007/s10047-021-01270-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Funayama, Toru
Noguchi, Hiroshi
Kumagai, Hiroshi
Sato, Kosuke
Yoshioka, Tomokazu
Yamazaki, Masashi
Unidirectional porous beta-tricalcium phosphate and hydroxyapatite artificial bone: a review of experimental evaluations and clinical applications
title Unidirectional porous beta-tricalcium phosphate and hydroxyapatite artificial bone: a review of experimental evaluations and clinical applications
title_full Unidirectional porous beta-tricalcium phosphate and hydroxyapatite artificial bone: a review of experimental evaluations and clinical applications
title_fullStr Unidirectional porous beta-tricalcium phosphate and hydroxyapatite artificial bone: a review of experimental evaluations and clinical applications
title_full_unstemmed Unidirectional porous beta-tricalcium phosphate and hydroxyapatite artificial bone: a review of experimental evaluations and clinical applications
title_short Unidirectional porous beta-tricalcium phosphate and hydroxyapatite artificial bone: a review of experimental evaluations and clinical applications
title_sort unidirectional porous beta-tricalcium phosphate and hydroxyapatite artificial bone: a review of experimental evaluations and clinical applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154753/
https://www.ncbi.nlm.nih.gov/pubmed/33893573
http://dx.doi.org/10.1007/s10047-021-01270-8
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