Immunohistochemical detection of procalcitonin in fibrolamellar hepatocellular carcinoma

A 25-year-old woman with fever and epigastric pain was referred to our hospital. Blood examination showed significant liver dysfunction, markedly high C-reactive protein (CRP 19.1 mg/dL) and procalcitonin (48.3 ng/mL) levels. Dynamic computed tomography showed a tumor approximately 120 mm in size in...

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Autores principales: Matsumoto, Kotaro, Kikuchi, Kentaro, Hara, Ayako, Tsunashima, Hiromichi, Tsuneyama, Koichi, Doi, Shinpei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154767/
https://www.ncbi.nlm.nih.gov/pubmed/33566306
http://dx.doi.org/10.1007/s12328-021-01354-1
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author Matsumoto, Kotaro
Kikuchi, Kentaro
Hara, Ayako
Tsunashima, Hiromichi
Tsuneyama, Koichi
Doi, Shinpei
author_facet Matsumoto, Kotaro
Kikuchi, Kentaro
Hara, Ayako
Tsunashima, Hiromichi
Tsuneyama, Koichi
Doi, Shinpei
author_sort Matsumoto, Kotaro
collection PubMed
description A 25-year-old woman with fever and epigastric pain was referred to our hospital. Blood examination showed significant liver dysfunction, markedly high C-reactive protein (CRP 19.1 mg/dL) and procalcitonin (48.3 ng/mL) levels. Dynamic computed tomography showed a tumor approximately 120 mm in size in the right lobe of the liver, but with no abscess formation. The patient was hospitalized and started on antibiotics; her CRP level improved, but the procalcitonin level did not decrease. Histopathological examination of the liver tumor biopsy revealed fibrolamellar hepatocellular carcinoma (FLC). Positive staining of the FLC with an anti-procalcitonin antibody suggested the production of procalcitonin.
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spelling pubmed-81547672021-06-01 Immunohistochemical detection of procalcitonin in fibrolamellar hepatocellular carcinoma Matsumoto, Kotaro Kikuchi, Kentaro Hara, Ayako Tsunashima, Hiromichi Tsuneyama, Koichi Doi, Shinpei Clin J Gastroenterol Case Report A 25-year-old woman with fever and epigastric pain was referred to our hospital. Blood examination showed significant liver dysfunction, markedly high C-reactive protein (CRP 19.1 mg/dL) and procalcitonin (48.3 ng/mL) levels. Dynamic computed tomography showed a tumor approximately 120 mm in size in the right lobe of the liver, but with no abscess formation. The patient was hospitalized and started on antibiotics; her CRP level improved, but the procalcitonin level did not decrease. Histopathological examination of the liver tumor biopsy revealed fibrolamellar hepatocellular carcinoma (FLC). Positive staining of the FLC with an anti-procalcitonin antibody suggested the production of procalcitonin. Springer Singapore 2021-02-10 2021 /pmc/articles/PMC8154767/ /pubmed/33566306 http://dx.doi.org/10.1007/s12328-021-01354-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Case Report
Matsumoto, Kotaro
Kikuchi, Kentaro
Hara, Ayako
Tsunashima, Hiromichi
Tsuneyama, Koichi
Doi, Shinpei
Immunohistochemical detection of procalcitonin in fibrolamellar hepatocellular carcinoma
title Immunohistochemical detection of procalcitonin in fibrolamellar hepatocellular carcinoma
title_full Immunohistochemical detection of procalcitonin in fibrolamellar hepatocellular carcinoma
title_fullStr Immunohistochemical detection of procalcitonin in fibrolamellar hepatocellular carcinoma
title_full_unstemmed Immunohistochemical detection of procalcitonin in fibrolamellar hepatocellular carcinoma
title_short Immunohistochemical detection of procalcitonin in fibrolamellar hepatocellular carcinoma
title_sort immunohistochemical detection of procalcitonin in fibrolamellar hepatocellular carcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154767/
https://www.ncbi.nlm.nih.gov/pubmed/33566306
http://dx.doi.org/10.1007/s12328-021-01354-1
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AT tsuneyamakoichi immunohistochemicaldetectionofprocalcitonininfibrolamellarhepatocellularcarcinoma
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