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T cell engaging bispecific antibodies targeting CD33 IgV and IgC domains for the treatment of acute myeloid leukemia

BACKGROUND: Acute myeloid leukemia (AML) remains one of the most challenging hematological malignancies. Despite progress in therapeutics, majority of patients succumb to this neoplasm. CD33 is a proven therapeutic target, given its expression on most AML cells. Almost all anti-CD33 antibodies targe...

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Detalles Bibliográficos
Autores principales:	Hoseini, Sayed Shahabuddin, Vadlamudi, Mallika, Espinosa-Cotton, Madelyn, Tran, Hoa, Feng, Yi, Guo, Hong-fen, Xu, Hong, Cheung, Irene, Cheung, Nai-Kong V
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Clinical/Translational Cancer Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154967/ https://www.ncbi.nlm.nih.gov/pubmed/34035113 http://dx.doi.org/10.1136/jitc-2021-002509

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