Targeting the epichaperome as an effective precision medicine approach in a novel PML-SYK fusion acute myeloid leukemia

The epichaperome is a new cancer target composed of hyperconnected networks of chaperome members that facilitate cell survival. Cancers with an altered chaperone configuration may be susceptible to epichaperome inhibitors. We developed a flow cytometry-based assay for evaluation and monitoring of ep...

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Detalles Bibliográficos
Autores principales: Sugita, Mayumi, Wilkes, David C., Bareja, Rohan, Eng, Kenneth W., Nataraj, Sarah, Jimenez-Flores, Reyna A., Yan, LunBiao, De Leon, Jeanne Pauline, Croyle, Jaclyn A., Kaner, Justin, Merugu, Swathi, Sharma, Sahil, MacDonald, Theresa Y., Noorzad, Zohal, Panchal, Palak, Pancirer, Danielle, Cheng, Shuhua, Xiang, Jenny Z., Olson, Luke, Van Besien, Koen, Rickman, David S., Mathew, Susan, Tam, Wayne, Rubin, Mark A., Beltran, Himisha, Sboner, Andrea, Hassane, Duane C., Chiosis, Gabriela, Elemento, Olivier, Roboz, Gail J., Mosquera, Juan Miguel, Guzman, Monica L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155064/
https://www.ncbi.nlm.nih.gov/pubmed/34040147
http://dx.doi.org/10.1038/s41698-021-00183-2

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