SON inhibits megakaryocytic differentiation via repressing RUNX1 and the megakaryocytic gene expression program in acute megakaryoblastic leukemia

A high incidence of acute megakaryoblastic leukemia (AMKL) in Down syndrome patients implies that chromosome 21 genes have a pivotal role in AMKL development, but the functional contribution of individual genes remains elusive. Here, we report that SON, a chromosome 21-encoded DNA- and RNA-binding p...

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Detalles Bibliográficos
Autores principales: Vukadin, Lana, Kim, Jung-Hyun, Park, Eun Young, Stone, Joshua K., Ungerleider, Nathan, Baddoo, Melody C., Kong, Hyun Kyung, Richard, Alexander, Tran, Johnny, Giannini, Hannah, Flemington, Erik K., Lim, Ssang-Taek Steve, Ahn, Eun-Young Erin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155101/
https://www.ncbi.nlm.nih.gov/pubmed/33247227
http://dx.doi.org/10.1038/s41417-020-00262-9

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