CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution

Antagonistic pleiotropy is a foundational theory that predicts aging-related diseases are the result of evolved genetic traits conferring advantages early in life. Here we examine CaMKII, a pluripotent signaling molecule that contributes to common aging-related diseases, and find that its activation...

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Detalles Bibliográficos
Autores principales: Wang, Qinchuan, Hernández-Ochoa, Erick O., Viswanathan, Meera C., Blum, Ian D., Do, Danh C., Granger, Jonathan M., Murphy, Kevin R., Wei, An-Chi, Aja, Susan, Liu, Naili, Antonescu, Corina M., Florea, Liliana D., Talbot, C. Conover, Mohr, David, Wagner, Kathryn R., Regot, Sergi, Lovering, Richard M., Gao, Peisong, Bianchet, Mario A., Wu, Mark N., Cammarato, Anthony, Schneider, Martin F., Bever, Gabriel S., Anderson, Mark E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155201/
https://www.ncbi.nlm.nih.gov/pubmed/34039988
http://dx.doi.org/10.1038/s41467-021-23549-3

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