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Oxaloacetate treatment preserves motor function in SOD1(G93A) mice and normalizes select neuroinflammation-related parameters in the spinal cord

Amyotrophic lateral sclerosis (ALS) remains a devastating motor neuron disease with limited treatment options. Oxaloacetate treatment has a neuroprotective effect in rodent models of seizure and neurodegeneration. Therefore, we treated the ALS model superoxide dismutase 1 (SOD1) (G93A) mice with oxa...

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Detalles Bibliográficos
Autores principales:	Tungtur, Sudheer K., Wilkins, Heather M., Rogers, Robert S., Badawi, Yomna, Sage, Jessica M., Agbas, Abdulbaki, Jawdat, Omar, Barohn, Richard J., Swerdlow, Russell H., Nishimune, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155202/ https://www.ncbi.nlm.nih.gov/pubmed/34040085 http://dx.doi.org/10.1038/s41598-021-90438-6

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