Cargando…
Association Between Childhood Neighborhood Quality and the Risk of Cognitive Dysfunction in Chinese Middle-Aged and Elderly Population: The Moderation Effect of Body Mass Index
Background: Identification of early modifiable factors is crucial to delay or prevent the development of cognitive impairment and reduce the social and economic burden. Objective: This study aimed to examine the longitudinal associations of childhood neighborhood quality (CNQ) with the risk of later...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155274/ https://www.ncbi.nlm.nih.gov/pubmed/34054503 http://dx.doi.org/10.3389/fnagi.2021.645189 |
_version_ | 1783699165961781248 |
---|---|
author | Xiong, Peng Liang, Xiaohua Chen, Haiyan Chen, Li Zuo, Lei Jing, Chunxia Hao, Guang |
author_facet | Xiong, Peng Liang, Xiaohua Chen, Haiyan Chen, Li Zuo, Lei Jing, Chunxia Hao, Guang |
author_sort | Xiong, Peng |
collection | PubMed |
description | Background: Identification of early modifiable factors is crucial to delay or prevent the development of cognitive impairment and reduce the social and economic burden. Objective: This study aimed to examine the longitudinal associations of childhood neighborhood quality (CNQ) with the risk of later-life cognitive dysfunction and the role of body mass index (BMI) in this association. Methods: A total of 8,289 community-dwelling middle-aged and elderly population from wave 2011, wave 2013, and wave 2015 of the China Health and Retirement Longitudinal Study (CHARLS) were included. Cognitive function and CNQ were measured by standardized questionnaires. Multilevel linear regression models were used to estimate the associations of CNQ and cognitive function. The interactions of BMI with CNQ in the progress of cognitive function were also estimated. Results: The participants with higher CNQ had a significantly low risk of cognitive impairment than those with lower CNQ score (β = 0.067, 95% CI: 0.031, 0.103), and the results remained similar (β = 0.039, 95% CI: 0.004, 0.075) after controlling other confounding variables. Furthermore, there was an interaction between BMI with CNQ score (P < 0.001) for the risk of cognitive impairment. In BMI-stratified analysis, we found that the association of CNQ and cognitive function was not statistically significant in overweight or obese population (β = 0.019, 95% CI: −0.032, 0.070), but was statistically significant in people with lower BMI (β = 0.059, 95% CI: 0.010, 0.107). Conclusions: Higher CNQ score is significantly associated with the lower risk of cognitive dysfunction in adulthood. BMI may moderate the associations of CNQ with the risk of cognitive function. |
format | Online Article Text |
id | pubmed-8155274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81552742021-05-28 Association Between Childhood Neighborhood Quality and the Risk of Cognitive Dysfunction in Chinese Middle-Aged and Elderly Population: The Moderation Effect of Body Mass Index Xiong, Peng Liang, Xiaohua Chen, Haiyan Chen, Li Zuo, Lei Jing, Chunxia Hao, Guang Front Aging Neurosci Neuroscience Background: Identification of early modifiable factors is crucial to delay or prevent the development of cognitive impairment and reduce the social and economic burden. Objective: This study aimed to examine the longitudinal associations of childhood neighborhood quality (CNQ) with the risk of later-life cognitive dysfunction and the role of body mass index (BMI) in this association. Methods: A total of 8,289 community-dwelling middle-aged and elderly population from wave 2011, wave 2013, and wave 2015 of the China Health and Retirement Longitudinal Study (CHARLS) were included. Cognitive function and CNQ were measured by standardized questionnaires. Multilevel linear regression models were used to estimate the associations of CNQ and cognitive function. The interactions of BMI with CNQ in the progress of cognitive function were also estimated. Results: The participants with higher CNQ had a significantly low risk of cognitive impairment than those with lower CNQ score (β = 0.067, 95% CI: 0.031, 0.103), and the results remained similar (β = 0.039, 95% CI: 0.004, 0.075) after controlling other confounding variables. Furthermore, there was an interaction between BMI with CNQ score (P < 0.001) for the risk of cognitive impairment. In BMI-stratified analysis, we found that the association of CNQ and cognitive function was not statistically significant in overweight or obese population (β = 0.019, 95% CI: −0.032, 0.070), but was statistically significant in people with lower BMI (β = 0.059, 95% CI: 0.010, 0.107). Conclusions: Higher CNQ score is significantly associated with the lower risk of cognitive dysfunction in adulthood. BMI may moderate the associations of CNQ with the risk of cognitive function. Frontiers Media S.A. 2021-05-13 /pmc/articles/PMC8155274/ /pubmed/34054503 http://dx.doi.org/10.3389/fnagi.2021.645189 Text en Copyright © 2021 Xiong, Liang, Chen, Chen, Zuo, Jing and Hao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Xiong, Peng Liang, Xiaohua Chen, Haiyan Chen, Li Zuo, Lei Jing, Chunxia Hao, Guang Association Between Childhood Neighborhood Quality and the Risk of Cognitive Dysfunction in Chinese Middle-Aged and Elderly Population: The Moderation Effect of Body Mass Index |
title | Association Between Childhood Neighborhood Quality and the Risk of Cognitive Dysfunction in Chinese Middle-Aged and Elderly Population: The Moderation Effect of Body Mass Index |
title_full | Association Between Childhood Neighborhood Quality and the Risk of Cognitive Dysfunction in Chinese Middle-Aged and Elderly Population: The Moderation Effect of Body Mass Index |
title_fullStr | Association Between Childhood Neighborhood Quality and the Risk of Cognitive Dysfunction in Chinese Middle-Aged and Elderly Population: The Moderation Effect of Body Mass Index |
title_full_unstemmed | Association Between Childhood Neighborhood Quality and the Risk of Cognitive Dysfunction in Chinese Middle-Aged and Elderly Population: The Moderation Effect of Body Mass Index |
title_short | Association Between Childhood Neighborhood Quality and the Risk of Cognitive Dysfunction in Chinese Middle-Aged and Elderly Population: The Moderation Effect of Body Mass Index |
title_sort | association between childhood neighborhood quality and the risk of cognitive dysfunction in chinese middle-aged and elderly population: the moderation effect of body mass index |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155274/ https://www.ncbi.nlm.nih.gov/pubmed/34054503 http://dx.doi.org/10.3389/fnagi.2021.645189 |
work_keys_str_mv | AT xiongpeng associationbetweenchildhoodneighborhoodqualityandtheriskofcognitivedysfunctioninchinesemiddleagedandelderlypopulationthemoderationeffectofbodymassindex AT liangxiaohua associationbetweenchildhoodneighborhoodqualityandtheriskofcognitivedysfunctioninchinesemiddleagedandelderlypopulationthemoderationeffectofbodymassindex AT chenhaiyan associationbetweenchildhoodneighborhoodqualityandtheriskofcognitivedysfunctioninchinesemiddleagedandelderlypopulationthemoderationeffectofbodymassindex AT chenli associationbetweenchildhoodneighborhoodqualityandtheriskofcognitivedysfunctioninchinesemiddleagedandelderlypopulationthemoderationeffectofbodymassindex AT zuolei associationbetweenchildhoodneighborhoodqualityandtheriskofcognitivedysfunctioninchinesemiddleagedandelderlypopulationthemoderationeffectofbodymassindex AT jingchunxia associationbetweenchildhoodneighborhoodqualityandtheriskofcognitivedysfunctioninchinesemiddleagedandelderlypopulationthemoderationeffectofbodymassindex AT haoguang associationbetweenchildhoodneighborhoodqualityandtheriskofcognitivedysfunctioninchinesemiddleagedandelderlypopulationthemoderationeffectofbodymassindex |