Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles

[Image: see text] Emerging therapeutic treatments based on the production of proteins by delivering mRNA have become increasingly important in recent times. While lipid nanoparticles (LNPs) are approved vehicles for small interfering RNA delivery, there are still challenges to use this formulation f...

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Detalles Bibliográficos
Autores principales: Sebastiani, Federica, Yanez Arteta, Marianna, Lerche, Michael, Porcar, Lionel, Lang, Christian, Bragg, Ryan A., Elmore, Charles S., Krishnamurthy, Venkata R., Russell, Robert A., Darwish, Tamim, Pichler, Harald, Waldie, Sarah, Moulin, Martine, Haertlein, Michael, Forsyth, V. Trevor, Lindfors, Lennart, Cárdenas, Marité
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155318/
https://www.ncbi.nlm.nih.gov/pubmed/33754708
http://dx.doi.org/10.1021/acsnano.0c10064

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