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Applying Genomic Epidemiology to Characterize a COVID-19 Outbreak in a Developmentally Disabled Adult Group Home Setting, Arizona

Individuals living in congregate settings, including those in group homes, have been disproportionately impacted by COVID-19 and may be at increased risk of exposure or infection due to underlying illness. In mid-May 2020, local public health officials responded to an outbreak of COVID-19 among staf...

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Autores principales: Yaglom, Hayley D., Gebhardt, Marette, Pfeiffer, Ashlyn, Ormsby, Mary Ellen, Jasso-Selles, Daniel E., Lemmer, Darrin, Folkerts, Megan L., French, Chris, Maurer, Matthew, Bowers, Jolene R., Engelthaler, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155364/
https://www.ncbi.nlm.nih.gov/pubmed/34055726
http://dx.doi.org/10.3389/fpubh.2021.668214
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author Yaglom, Hayley D.
Gebhardt, Marette
Pfeiffer, Ashlyn
Ormsby, Mary Ellen
Jasso-Selles, Daniel E.
Lemmer, Darrin
Folkerts, Megan L.
French, Chris
Maurer, Matthew
Bowers, Jolene R.
Engelthaler, David M.
author_facet Yaglom, Hayley D.
Gebhardt, Marette
Pfeiffer, Ashlyn
Ormsby, Mary Ellen
Jasso-Selles, Daniel E.
Lemmer, Darrin
Folkerts, Megan L.
French, Chris
Maurer, Matthew
Bowers, Jolene R.
Engelthaler, David M.
author_sort Yaglom, Hayley D.
collection PubMed
description Individuals living in congregate settings, including those in group homes, have been disproportionately impacted by COVID-19 and may be at increased risk of exposure or infection due to underlying illness. In mid-May 2020, local public health officials responded to an outbreak of COVID-19 among staff and residents associated with a multi-residential group home that provides care for adults with intellectual and developmental disabilities. Samples were collected at 16 of the homes. In four of the homes all the residents tested positive, and in the remaining 12 houses where samples were collected, all residents tested negative. Of the 152 individuals tested, 15/58 (25.9%) residents and 27/94 (28.7%) staff were positive for SARS-CoV-2, including eight hospitalizations and four deaths. Phylogenetic analysis of genomes from this outbreak in the context of genomes from Northern Arizona shows that very few mutations separate the samples from this outbreak. A potential transmission network was developed to illustrate person-place epidemiologic linkages and further demonstrates the dynamic connections between staff and residents with respect to each group home location. Epidemiologic and genomic evidence correlate, and suggest that asymptomatic infected staff likely introduced and spread COVID-19 in this setting. Implementation of public health prevention measures alongside rapid genomic analysis can help guide policy development and guide management efforts to prevent and mitigate future outbreaks.
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spelling pubmed-81553642021-05-28 Applying Genomic Epidemiology to Characterize a COVID-19 Outbreak in a Developmentally Disabled Adult Group Home Setting, Arizona Yaglom, Hayley D. Gebhardt, Marette Pfeiffer, Ashlyn Ormsby, Mary Ellen Jasso-Selles, Daniel E. Lemmer, Darrin Folkerts, Megan L. French, Chris Maurer, Matthew Bowers, Jolene R. Engelthaler, David M. Front Public Health Public Health Individuals living in congregate settings, including those in group homes, have been disproportionately impacted by COVID-19 and may be at increased risk of exposure or infection due to underlying illness. In mid-May 2020, local public health officials responded to an outbreak of COVID-19 among staff and residents associated with a multi-residential group home that provides care for adults with intellectual and developmental disabilities. Samples were collected at 16 of the homes. In four of the homes all the residents tested positive, and in the remaining 12 houses where samples were collected, all residents tested negative. Of the 152 individuals tested, 15/58 (25.9%) residents and 27/94 (28.7%) staff were positive for SARS-CoV-2, including eight hospitalizations and four deaths. Phylogenetic analysis of genomes from this outbreak in the context of genomes from Northern Arizona shows that very few mutations separate the samples from this outbreak. A potential transmission network was developed to illustrate person-place epidemiologic linkages and further demonstrates the dynamic connections between staff and residents with respect to each group home location. Epidemiologic and genomic evidence correlate, and suggest that asymptomatic infected staff likely introduced and spread COVID-19 in this setting. Implementation of public health prevention measures alongside rapid genomic analysis can help guide policy development and guide management efforts to prevent and mitigate future outbreaks. Frontiers Media S.A. 2021-05-13 /pmc/articles/PMC8155364/ /pubmed/34055726 http://dx.doi.org/10.3389/fpubh.2021.668214 Text en Copyright © 2021 Yaglom, Gebhardt, Pfeiffer, Ormsby, Jasso-Selles, Lemmer, Folkerts, French, Maurer, Bowers and Engelthaler. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Yaglom, Hayley D.
Gebhardt, Marette
Pfeiffer, Ashlyn
Ormsby, Mary Ellen
Jasso-Selles, Daniel E.
Lemmer, Darrin
Folkerts, Megan L.
French, Chris
Maurer, Matthew
Bowers, Jolene R.
Engelthaler, David M.
Applying Genomic Epidemiology to Characterize a COVID-19 Outbreak in a Developmentally Disabled Adult Group Home Setting, Arizona
title Applying Genomic Epidemiology to Characterize a COVID-19 Outbreak in a Developmentally Disabled Adult Group Home Setting, Arizona
title_full Applying Genomic Epidemiology to Characterize a COVID-19 Outbreak in a Developmentally Disabled Adult Group Home Setting, Arizona
title_fullStr Applying Genomic Epidemiology to Characterize a COVID-19 Outbreak in a Developmentally Disabled Adult Group Home Setting, Arizona
title_full_unstemmed Applying Genomic Epidemiology to Characterize a COVID-19 Outbreak in a Developmentally Disabled Adult Group Home Setting, Arizona
title_short Applying Genomic Epidemiology to Characterize a COVID-19 Outbreak in a Developmentally Disabled Adult Group Home Setting, Arizona
title_sort applying genomic epidemiology to characterize a covid-19 outbreak in a developmentally disabled adult group home setting, arizona
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155364/
https://www.ncbi.nlm.nih.gov/pubmed/34055726
http://dx.doi.org/10.3389/fpubh.2021.668214
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