Arylboronic Acid Catalyzed C-Alkylation and Allylation Reactions Using Benzylic Alcohols

[Image: see text] The arylboronic acid catalyzed dehydrative C-alkylation of 1,3-diketones and 1,3-ketoesters using secondary benzylic alcohols as the electrophile is reported, forming new C–C bonds (19 examples, up to 98% yield) with the release of water as the only byproduct. The process is also a...

Descripción completa

Detalles Bibliográficos
Autores principales: Estopiñá-Durán, Susana, Mclean, Euan B., Donnelly, Liam J., Hockin, Bryony M., Taylor, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155392/
https://www.ncbi.nlm.nih.gov/pubmed/32959662
http://dx.doi.org/10.1021/acs.orglett.0c02736
Descripción
Sumario:[Image: see text] The arylboronic acid catalyzed dehydrative C-alkylation of 1,3-diketones and 1,3-ketoesters using secondary benzylic alcohols as the electrophile is reported, forming new C–C bonds (19 examples, up to 98% yield) with the release of water as the only byproduct. The process is also applicable to the allylation of benzylic alcohols using allyltrimethylsilane as the nucleophile (12 examples, up to 96% yield).

Ejemplares similares