Cargando…
TRIM71 Deficiency Causes Germ Cell Loss During Mouse Embryogenesis and Is Associated With Human Male Infertility
Mutations affecting the germline can result in infertility or the generation of germ cell tumors (GCT), highlighting the need to identify and characterize the genes controlling germ cell development. The RNA-binding protein and E3 ubiquitin ligase TRIM71 is essential for embryogenesis, and its expre...
Autores principales: | Torres-Fernández, Lucia A., Emich, Jana, Port, Yasmine, Mitschka, Sibylle, Wöste, Marius, Schneider, Simon, Fietz, Daniela, Oud, Manon S., Di Persio, Sara, Neuhaus, Nina, Kliesch, Sabine, Hölzel, Michael, Schorle, Hubert, Friedrich, Corinna, Tüttelmann, Frank, Kolanus, Waldemar |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155544/ https://www.ncbi.nlm.nih.gov/pubmed/34055789 http://dx.doi.org/10.3389/fcell.2021.658966 |
Ejemplares similares
-
Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71
por: Mitschka, Sibylle, et al.
Publicado: (2015) -
The ubiquitin ligase LIN41/TRIM71 targets p53 to antagonize cell death and differentiation pathways during stem cell differentiation
por: Nguyen, Duong Thi Thuy, et al.
Publicado: (2017) -
The stem cell–specific protein TRIM71 inhibits maturation and activity of the prodifferentiation miRNA let-7 via two independent molecular mechanisms
por: Torres-Fernández, Lucia A., et al.
Publicado: (2021) -
The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A/p21
por: Torres-Fernández, Lucia A, et al.
Publicado: (2019) -
Transcriptome analyses in infertile men reveal germ cell–specific expression and splicing patterns
por: Siebert-Kuss, Lara M, et al.
Publicado: (2022)