Cargando…

Guhong Injection Protects Against Apoptosis in Cerebral Ischemia by Maintaining Cerebral Microvasculature and Mitochondrial Integrity Through the PI3K/AKT Pathway

Guhong injection (GHI) can be used for the treatment of ischemic stroke. We investigated the antiapoptotic activity of GHI, its ability to repair the cerebral microvessels and mitochondria, and the PI3K/AKT signaling pathway of GHI against cerebral ischemia. Western blot and immunohistochemical anal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Huifen, He, Yu, Zhu, Jiaqi, Lin, Xiaojie, Chen, Juan, Shao, Chongyu, Wan, Haitong, Yang, Jiehong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155598/ https://www.ncbi.nlm.nih.gov/pubmed/34054531 http://dx.doi.org/10.3389/fphar.2021.650983

Ejemplares similares

Guhong Injection Alleviates Cerebral Ischemia–Reperfusion Injury via the PKC/HIF-1α Pathway in Rats
por: Yu, Li, et al.
Publicado: (2021)

Neuroprotective Effect of Danhong Injection on Cerebral Ischemia-Reperfusion Injury in Rats by Activation of the PI3K-Akt Pathway
por: Feng, Chen, et al.
Publicado: (2020)

Hydroxysafflor Yellow A and Anhydrosafflor Yellow B Protect Against Cerebral Ischemia/Reperfusion Injury by Attenuating Oxidative Stress and Apoptosis via the Silent Information Regulator 1 Signaling Pathway
por: Fangma, Yijia, et al.
Publicado: (2021)

Pharmacokinetics of Active Components From Guhong Injection in Normal and Pathological Rat Models of Cerebral Ischemia: A Comparative Study
por: Yu, Li, et al.
Publicado: (2018)

Dan Hong Injection Protects Against Cardiomyocytes Apoptosis by Maintaining Mitochondrial Integrity Through Keap1/Nuclear Factor Erythroid 2-Related Factor 2/JNK Pathway
por: Zhang, Ling, et al.
Publicado: (2020)

Danhong Injection Attenuates Cerebral Ischemia-Reperfusion Injury in Rats Through the Suppression of the Neuroinflammation
por: Du, Haixia, et al.
Publicado: (2021)

Spectrum effect correlation of yangyin tongnao granules on cerebral ischemia-reperfusion injury rats
por: Zhang, Yangyang, et al.
Publicado: (2022)

Comparative efficacy of Honghua class injections for treating acute ischemic stroke: A Bayesian network meta-analysis of randomized controlled trials
por: Li, Lan, et al.
Publicado: (2022)

Chemical composition, pharmacology and pharmacokinetic studies of GuHong injection in the treatment of ischemic stroke
por: Wang, Qiuyue, et al.
Publicado: (2023)

Recent Advances in Chinese Herbal Medicine for Cerebral Ischemic Reperfusion Injury
por: Huang, Ping, et al.
Publicado: (2022)

Comparative Pharmacokinetics of Hydrophilic Components in Salvia miltiorrhiza Bge. and Carthamus tinctorius L. in Rats That Underwent Cerebral Ischemia Reperfusion Using an HPLC-DAD Method
por: Zhao, Xixi, et al.
Publicado: (2020)

Guhong Injection Prevents Ischemic Stroke-Induced Neuro-Inflammation and Neuron Loss Through Regulation of C5ar1
por: Zhang, Jingjing, et al.
Publicado: (2022)

Compatibility of ingredients of Danshen (Radix Salviae Miltiorrhizae) and Honghua (Flos Carthami) and their protective effects on cerebral ischemia-reperfusion injury in rats
por: Wan, Haoyu, et al.
Publicado: (2021)

Sodium danshensu attenuates cerebral ischemia–reperfusion injury by targeting AKT1
por: Gao, Qing, et al.
Publicado: (2022)

Screening of Antiviral Components of Ma Huang Tang and Investigation on the Ephedra Alkaloids Efficacy on Influenza Virus Type A
por: Wei, Wenyang, et al.
Publicado: (2019)

Puerarin inhibited oxidative stress and alleviated cerebral ischemia-reperfusion injury through PI3K/Akt/Nrf2 signaling pathway
por: Zhang, Qianqian, et al.
Publicado: (2023)

Astragali Radix Isoflavones Synergistically Alleviate Cerebral Ischemia and Reperfusion Injury Via Activating Estrogen Receptor-PI3K-Akt Signaling Pathway
por: Gu, Yong, et al.
Publicado: (2021)

Network Pharmacology and Molecular Docking-Based Mechanism Study to Reveal the Protective Effect of Salvianolic Acid C in a Rat Model of Ischemic Stroke
por: Yang, Yuting, et al.
Publicado: (2022)

Retraction: Astragali radix isoflavones synergistically alleviate cerebral ischemia and reperfusion injury via activating estrogen receptor-PI3K-Akt signaling pathway
Publicado: (2023)

Astragaloside IV Alleviates Infarction Induced Cardiomyocyte Injury by Improving Mitochondrial Morphology and Function
por: Zhang, Wen, et al.
Publicado: (2022)

Metabolomics: A useful tool for ischemic stroke research
por: Li, Wentao, et al.
Publicado: (2023)

Notoginsenoside R1 Improves Cerebral Ischemia/Reperfusion Injury by Promoting Neurogenesis via the BDNF/Akt/CREB Pathway
por: Zhu, Ting, et al.
Publicado: (2021)

PET Demonstrates Functional Recovery after Treatment by Danhong Injection in a Rat Model of Cerebral Ischemic-Reperfusion Injury
por: Wang, Zefeng, et al.
Publicado: (2014)

Neuroprotective effects of metformin on cerebral ischemia‐reperfusion injury by regulating PI3K/Akt pathway
por: Ruan, Cailian, et al.
Publicado: (2021)

Mechanisms Underlying Curcumin-Induced Neuroprotection in Cerebral Ischemia
por: Fan, Feng, et al.
Publicado: (2022)

Anti-Inflammatory Effects of Natural Products on Cerebral Ischemia
por: Shang, Yuanhong, et al.
Publicado: (2022)

Efficacy of Guhong injection versus Butylphthalide and Sodium Chloride Injection for mild ischemic stroke: A multicenter controlled study
por: Zhang, Wei-Wei, et al.
Publicado: (2022)

Efficacy and safety of Guhong injection for coronary heart disease: A protocol for systematic review and meta-analysis
por: Che, Sihua, et al.
Publicado: (2021)

Neuroprotective Effect for Cerebral Ischemia by Natural Products: A Review
por: Xie, Qian, et al.
Publicado: (2021)

Metabolomics profiling to characterize cerebral ischemia-reperfusion injury in mice
por: Chen, Qiong, et al.
Publicado: (2023)

Experimental Evidence of Buyang Huanwu Decoction and Related Modern Preparations (Naoxintong Capsule and Yangyin Tongnao Granule) in Treating Cerebral Ischemia: Intestinal Microorganisms and Transcriptomics in Rats
por: Yin, Junjun, et al.
Publicado: (2022)

EGCG protects the mouse brain against cerebral ischemia/reperfusion injury by suppressing autophagy via the AKT/AMPK/mTOR phosphorylation pathway
por: Wang, Li, et al.
Publicado: (2022)

Transcriptomic Study Reveals Recovery of Impaired Astrocytes Contribute to Neuroprotective Effects of Danhong Injection Against Cerebral Ischemia/Reperfusion-Induced Injury
por: Qian, Jing, et al.
Publicado: (2018)

Potential application of traditional Chinese medicine in cerebral ischemia—Focusing on ferroptosis
por: Zhao, Fengyan, et al.
Publicado: (2022)

Efficacy and safety of Guhong injection for treating coronary microvascular disease: study protocol for a randomized controlled trial
por: Jieqin, Zhuang, et al.
Publicado: (2020)

Ligustilide Attenuates Ischemia Reperfusion-Induced Hippocampal Neuronal Apoptosis via Activating the PI3K/Akt Pathway
por: Wu, Qian, et al.
Publicado: (2020)

Modelling the effects of cerebral microvasculature morphology on oxygen transport
por: Park, Chang Sub, et al.
Publicado: (2016)

Xingnaojing Injection Protects against Cerebral Ischemia Reperfusion Injury via PI3K/Akt-Mediated eNOS Phosphorylation
por: Zhang, Yue-Ming, et al.
Publicado: (2018)

Treatment of Cerebral Ischemia Through NMDA Receptors: Metabotropic Signaling and Future Directions
por: Li, Yuanyuan, et al.
Publicado: (2022)

Gastrin Attenuates Renal Ischemia/Reperfusion Injury by a PI3K/Akt/Bad-Mediated Anti-apoptosis Signaling
por: Liu, Chao, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_a77vc41bvh3esl0jml4gqjgl4k