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Natural Compounds as Medical Strategies in the Prevention and Treatment of Psychiatric Disorders Seen in Neurological Diseases

Psychiatric disorders are frequently encountered in many neurological disorders, such as Alzheimer’s and Parkinson diseases along with epilepsy, migraine, essential tremors, and stroke. The most common comorbid diagnoses in neurological diseases are depression and anxiety disorders along with cognit...

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Autores principales: Küpeli Akkol, Esra, Tatlı Çankaya, Irem, Şeker Karatoprak, Gökçe, Carpar, Elif, Sobarzo-Sánchez, Eduardo, Capasso, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155682/
https://www.ncbi.nlm.nih.gov/pubmed/34054540
http://dx.doi.org/10.3389/fphar.2021.669638
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author Küpeli Akkol, Esra
Tatlı Çankaya, Irem
Şeker Karatoprak, Gökçe
Carpar, Elif
Sobarzo-Sánchez, Eduardo
Capasso, Raffaele
author_facet Küpeli Akkol, Esra
Tatlı Çankaya, Irem
Şeker Karatoprak, Gökçe
Carpar, Elif
Sobarzo-Sánchez, Eduardo
Capasso, Raffaele
author_sort Küpeli Akkol, Esra
collection PubMed
description Psychiatric disorders are frequently encountered in many neurological disorders, such as Alzheimer’s and Parkinson diseases along with epilepsy, migraine, essential tremors, and stroke. The most common comorbid diagnoses in neurological diseases are depression and anxiety disorders along with cognitive impairment. Whether the underlying reason is due to common neurochemical mechanisms or loss of previous functioning level, comorbidities are often overlooked. Various treatment options are available, such as pharmacological treatments, cognitive-behavioral therapy, somatic interventions, or electroconvulsive therapy. However oral antidepressant therapy may have some disadvantages, such as interaction with other medications, low tolerability due to side effects, and low efficiency. Natural compounds of plant origin are extensively researched to find a better and safer alternative treatment. Experimental studies have shown that phytochemicals such as alkaloids, terpenes, flavonoids, phenolic acids as well as lipids have significant potential in in vitro and in vivo models of psychiatric disorders. In this review, various efficacy of natural products in in vitro and in vivo studies on neuroprotective and their roles in psychiatric disorders are examined and their neuro-therapeutic potentials are shed light.
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spelling pubmed-81556822021-05-28 Natural Compounds as Medical Strategies in the Prevention and Treatment of Psychiatric Disorders Seen in Neurological Diseases Küpeli Akkol, Esra Tatlı Çankaya, Irem Şeker Karatoprak, Gökçe Carpar, Elif Sobarzo-Sánchez, Eduardo Capasso, Raffaele Front Pharmacol Pharmacology Psychiatric disorders are frequently encountered in many neurological disorders, such as Alzheimer’s and Parkinson diseases along with epilepsy, migraine, essential tremors, and stroke. The most common comorbid diagnoses in neurological diseases are depression and anxiety disorders along with cognitive impairment. Whether the underlying reason is due to common neurochemical mechanisms or loss of previous functioning level, comorbidities are often overlooked. Various treatment options are available, such as pharmacological treatments, cognitive-behavioral therapy, somatic interventions, or electroconvulsive therapy. However oral antidepressant therapy may have some disadvantages, such as interaction with other medications, low tolerability due to side effects, and low efficiency. Natural compounds of plant origin are extensively researched to find a better and safer alternative treatment. Experimental studies have shown that phytochemicals such as alkaloids, terpenes, flavonoids, phenolic acids as well as lipids have significant potential in in vitro and in vivo models of psychiatric disorders. In this review, various efficacy of natural products in in vitro and in vivo studies on neuroprotective and their roles in psychiatric disorders are examined and their neuro-therapeutic potentials are shed light. Frontiers Media S.A. 2021-05-13 /pmc/articles/PMC8155682/ /pubmed/34054540 http://dx.doi.org/10.3389/fphar.2021.669638 Text en Copyright © 2021 Küpeli Akkol, Tatlı Çankaya, Şeker Karatoprak, Carpar, Sobarzo-Sánchez and Capasso. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Küpeli Akkol, Esra
Tatlı Çankaya, Irem
Şeker Karatoprak, Gökçe
Carpar, Elif
Sobarzo-Sánchez, Eduardo
Capasso, Raffaele
Natural Compounds as Medical Strategies in the Prevention and Treatment of Psychiatric Disorders Seen in Neurological Diseases
title Natural Compounds as Medical Strategies in the Prevention and Treatment of Psychiatric Disorders Seen in Neurological Diseases
title_full Natural Compounds as Medical Strategies in the Prevention and Treatment of Psychiatric Disorders Seen in Neurological Diseases
title_fullStr Natural Compounds as Medical Strategies in the Prevention and Treatment of Psychiatric Disorders Seen in Neurological Diseases
title_full_unstemmed Natural Compounds as Medical Strategies in the Prevention and Treatment of Psychiatric Disorders Seen in Neurological Diseases
title_short Natural Compounds as Medical Strategies in the Prevention and Treatment of Psychiatric Disorders Seen in Neurological Diseases
title_sort natural compounds as medical strategies in the prevention and treatment of psychiatric disorders seen in neurological diseases
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155682/
https://www.ncbi.nlm.nih.gov/pubmed/34054540
http://dx.doi.org/10.3389/fphar.2021.669638
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