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Association of the OPRM1 A118G polymorphism and Pavlovian-to-instrumental transfer: Clinical relevance for alcohol dependence

BACKGROUND: Pavlovian-to-instrumental transfer (PIT) quantifies the extent to which a stimulus that has been associated with reward or punishment alters operant behaviour. In alcohol dependence (AD), the PIT effect serves as a paradigmatic model of cue-induced relapse. Preclinical studies have sugge...

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Autores principales: Sebold, Miriam, Garbusow, Maria, Cerci, Deniz, Chen, Ke, Sommer, Christian, Huys, Quentin JM, Nebe, Stephan, Rapp, Michael, Veer, Ilya M, Zimmermann, Ulrich S, Smolka, Michael N, Walter, Henrik, Heinz, Andreas, Friedel, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155738/
https://www.ncbi.nlm.nih.gov/pubmed/33726538
http://dx.doi.org/10.1177/0269881121991992
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author Sebold, Miriam
Garbusow, Maria
Cerci, Deniz
Chen, Ke
Sommer, Christian
Huys, Quentin JM
Nebe, Stephan
Rapp, Michael
Veer, Ilya M
Zimmermann, Ulrich S
Smolka, Michael N
Walter, Henrik
Heinz, Andreas
Friedel, Eva
author_facet Sebold, Miriam
Garbusow, Maria
Cerci, Deniz
Chen, Ke
Sommer, Christian
Huys, Quentin JM
Nebe, Stephan
Rapp, Michael
Veer, Ilya M
Zimmermann, Ulrich S
Smolka, Michael N
Walter, Henrik
Heinz, Andreas
Friedel, Eva
author_sort Sebold, Miriam
collection PubMed
description BACKGROUND: Pavlovian-to-instrumental transfer (PIT) quantifies the extent to which a stimulus that has been associated with reward or punishment alters operant behaviour. In alcohol dependence (AD), the PIT effect serves as a paradigmatic model of cue-induced relapse. Preclinical studies have suggested a critical role of the opioid system in modulating Pavlovian–instrumental interactions. The A118G polymorphism of the OPRM1 gene affects opioid receptor availability and function. Furthermore, this polymorphism interacts with cue-induced approach behaviour and is a potential biomarker for pharmacological treatment response in AD. In this study, we tested whether the OPRM1 polymorphism is associated with the PIT effect and relapse in AD. METHODS: Using a PIT task, we examined three independent samples: young healthy subjects (N = 161), detoxified alcohol-dependent patients (N = 186) and age-matched healthy controls (N = 105). We used data from a larger study designed to assess the role of learning mechanisms in the development and maintenance of AD. Subjects were genotyped for the A118G (rs1799971) polymorphism of the OPRM1 gene. Relapse was assessed after three months. RESULTS: In all three samples, participants with the minor OPRM1 G-Allele (G+ carriers) showed increased expression of the PIT effect in the absence of learning differences. Relapse was not associated with the OPRM1 polymorphism. Instead, G+ carriers displaying increased PIT effects were particularly prone to relapse. CONCLUSION: These results support a role for the opioid system in incentive salience motivation. Furthermore, they inform a mechanistic model of aberrant salience processing and are in line with the pharmacological potential of opioid receptor targets in the treatment of AD.
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spelling pubmed-81557382021-06-09 Association of the OPRM1 A118G polymorphism and Pavlovian-to-instrumental transfer: Clinical relevance for alcohol dependence Sebold, Miriam Garbusow, Maria Cerci, Deniz Chen, Ke Sommer, Christian Huys, Quentin JM Nebe, Stephan Rapp, Michael Veer, Ilya M Zimmermann, Ulrich S Smolka, Michael N Walter, Henrik Heinz, Andreas Friedel, Eva J Psychopharmacol Original Papers BACKGROUND: Pavlovian-to-instrumental transfer (PIT) quantifies the extent to which a stimulus that has been associated with reward or punishment alters operant behaviour. In alcohol dependence (AD), the PIT effect serves as a paradigmatic model of cue-induced relapse. Preclinical studies have suggested a critical role of the opioid system in modulating Pavlovian–instrumental interactions. The A118G polymorphism of the OPRM1 gene affects opioid receptor availability and function. Furthermore, this polymorphism interacts with cue-induced approach behaviour and is a potential biomarker for pharmacological treatment response in AD. In this study, we tested whether the OPRM1 polymorphism is associated with the PIT effect and relapse in AD. METHODS: Using a PIT task, we examined three independent samples: young healthy subjects (N = 161), detoxified alcohol-dependent patients (N = 186) and age-matched healthy controls (N = 105). We used data from a larger study designed to assess the role of learning mechanisms in the development and maintenance of AD. Subjects were genotyped for the A118G (rs1799971) polymorphism of the OPRM1 gene. Relapse was assessed after three months. RESULTS: In all three samples, participants with the minor OPRM1 G-Allele (G+ carriers) showed increased expression of the PIT effect in the absence of learning differences. Relapse was not associated with the OPRM1 polymorphism. Instead, G+ carriers displaying increased PIT effects were particularly prone to relapse. CONCLUSION: These results support a role for the opioid system in incentive salience motivation. Furthermore, they inform a mechanistic model of aberrant salience processing and are in line with the pharmacological potential of opioid receptor targets in the treatment of AD. SAGE Publications 2021-03-16 2021-05 /pmc/articles/PMC8155738/ /pubmed/33726538 http://dx.doi.org/10.1177/0269881121991992 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Papers
Sebold, Miriam
Garbusow, Maria
Cerci, Deniz
Chen, Ke
Sommer, Christian
Huys, Quentin JM
Nebe, Stephan
Rapp, Michael
Veer, Ilya M
Zimmermann, Ulrich S
Smolka, Michael N
Walter, Henrik
Heinz, Andreas
Friedel, Eva
Association of the OPRM1 A118G polymorphism and Pavlovian-to-instrumental transfer: Clinical relevance for alcohol dependence
title Association of the OPRM1 A118G polymorphism and Pavlovian-to-instrumental transfer: Clinical relevance for alcohol dependence
title_full Association of the OPRM1 A118G polymorphism and Pavlovian-to-instrumental transfer: Clinical relevance for alcohol dependence
title_fullStr Association of the OPRM1 A118G polymorphism and Pavlovian-to-instrumental transfer: Clinical relevance for alcohol dependence
title_full_unstemmed Association of the OPRM1 A118G polymorphism and Pavlovian-to-instrumental transfer: Clinical relevance for alcohol dependence
title_short Association of the OPRM1 A118G polymorphism and Pavlovian-to-instrumental transfer: Clinical relevance for alcohol dependence
title_sort association of the oprm1 a118g polymorphism and pavlovian-to-instrumental transfer: clinical relevance for alcohol dependence
topic Original Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155738/
https://www.ncbi.nlm.nih.gov/pubmed/33726538
http://dx.doi.org/10.1177/0269881121991992
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