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Serum endocan and endothelial dysfunction in childhood acute lymphoblastic leukemia survivors: a tertiary center experience

BACKGROUND: An increased risk of cardiovascular complications is reported in survivors of childhood acute lymphoblastic leukemia (ALL). Early identification of impaired vascular health may allow for early interventions to improve outcomes. AIM: The study was conducted to assess the endothelial dysfu...

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Autores principales: Sherief, Laila M., Abd El-khalek, Elhamy R., Libda, Ibrahim A., Gaber, Osama A., Kamal, Naglaa M., Soliman, Basma K., Mokhtar, Wesam A., Mokhtar, Ghada A., Salah, Hosam E., Kamar, Gehad M., Zakaria, Marwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155763/
https://www.ncbi.nlm.nih.gov/pubmed/34104378
http://dx.doi.org/10.1177/20406223211015963
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author Sherief, Laila M.
Abd El-khalek, Elhamy R.
Libda, Ibrahim A.
Gaber, Osama A.
Kamal, Naglaa M.
Soliman, Basma K.
Mokhtar, Wesam A.
Mokhtar, Ghada A.
Salah, Hosam E.
Kamar, Gehad M.
Zakaria, Marwa
author_facet Sherief, Laila M.
Abd El-khalek, Elhamy R.
Libda, Ibrahim A.
Gaber, Osama A.
Kamal, Naglaa M.
Soliman, Basma K.
Mokhtar, Wesam A.
Mokhtar, Ghada A.
Salah, Hosam E.
Kamar, Gehad M.
Zakaria, Marwa
author_sort Sherief, Laila M.
collection PubMed
description BACKGROUND: An increased risk of cardiovascular complications is reported in survivors of childhood acute lymphoblastic leukemia (ALL). Early identification of impaired vascular health may allow for early interventions to improve outcomes. AIM: The study was conducted to assess the endothelial dysfunction in ALL survivors using a new marker, serum endocan, and measurement of the mean common carotid arteries intima media thickness (cIMT). METHODS: A case-control study was conducted on 100 childhood ALL survivors (aged 6–18 years), with 80 healthy age and sex-matched children as a control group. Lipid profile, hepatitis markers, and serum ferritin where measured, in addition to the measurement of serum endocan. and cIMT by B-mode high-resolution ultrasonography for all study participants. RESULTS: Triglycerides, total cholesterol, post prandial glucose, and serum ferritin were significantly higher in ALL survivors than controls (p < 0.05). Dyslipidemia was detected in 6% of ALL survivors. ALL survivors showed statistically higher serum endocan levels (470.41 ± 556.1 ng/l, versus, 225.94 ± 185.2 ng/l, respectively) and increased cIMT levels compared with the control group (0.650 ± 0.129 mm versus 0.320 ± 0.095 mm, respectively) p < 0.05. Serum endocan was positively correlated with cIMT and blood cholesterol. CONCLUSIONS: The survivors of childhood ALL demonstrated an elevated level of serum endocan and increased cIMT. These can be used as predictors of endothelial dysfunction, and, as a consequence, the risk of developing premature atherosclerosis.
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spelling pubmed-81557632021-06-07 Serum endocan and endothelial dysfunction in childhood acute lymphoblastic leukemia survivors: a tertiary center experience Sherief, Laila M. Abd El-khalek, Elhamy R. Libda, Ibrahim A. Gaber, Osama A. Kamal, Naglaa M. Soliman, Basma K. Mokhtar, Wesam A. Mokhtar, Ghada A. Salah, Hosam E. Kamar, Gehad M. Zakaria, Marwa Ther Adv Chronic Dis Original Research BACKGROUND: An increased risk of cardiovascular complications is reported in survivors of childhood acute lymphoblastic leukemia (ALL). Early identification of impaired vascular health may allow for early interventions to improve outcomes. AIM: The study was conducted to assess the endothelial dysfunction in ALL survivors using a new marker, serum endocan, and measurement of the mean common carotid arteries intima media thickness (cIMT). METHODS: A case-control study was conducted on 100 childhood ALL survivors (aged 6–18 years), with 80 healthy age and sex-matched children as a control group. Lipid profile, hepatitis markers, and serum ferritin where measured, in addition to the measurement of serum endocan. and cIMT by B-mode high-resolution ultrasonography for all study participants. RESULTS: Triglycerides, total cholesterol, post prandial glucose, and serum ferritin were significantly higher in ALL survivors than controls (p < 0.05). Dyslipidemia was detected in 6% of ALL survivors. ALL survivors showed statistically higher serum endocan levels (470.41 ± 556.1 ng/l, versus, 225.94 ± 185.2 ng/l, respectively) and increased cIMT levels compared with the control group (0.650 ± 0.129 mm versus 0.320 ± 0.095 mm, respectively) p < 0.05. Serum endocan was positively correlated with cIMT and blood cholesterol. CONCLUSIONS: The survivors of childhood ALL demonstrated an elevated level of serum endocan and increased cIMT. These can be used as predictors of endothelial dysfunction, and, as a consequence, the risk of developing premature atherosclerosis. SAGE Publications 2021-05-25 /pmc/articles/PMC8155763/ /pubmed/34104378 http://dx.doi.org/10.1177/20406223211015963 Text en © The Author(s), 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Sherief, Laila M.
Abd El-khalek, Elhamy R.
Libda, Ibrahim A.
Gaber, Osama A.
Kamal, Naglaa M.
Soliman, Basma K.
Mokhtar, Wesam A.
Mokhtar, Ghada A.
Salah, Hosam E.
Kamar, Gehad M.
Zakaria, Marwa
Serum endocan and endothelial dysfunction in childhood acute lymphoblastic leukemia survivors: a tertiary center experience
title Serum endocan and endothelial dysfunction in childhood acute lymphoblastic leukemia survivors: a tertiary center experience
title_full Serum endocan and endothelial dysfunction in childhood acute lymphoblastic leukemia survivors: a tertiary center experience
title_fullStr Serum endocan and endothelial dysfunction in childhood acute lymphoblastic leukemia survivors: a tertiary center experience
title_full_unstemmed Serum endocan and endothelial dysfunction in childhood acute lymphoblastic leukemia survivors: a tertiary center experience
title_short Serum endocan and endothelial dysfunction in childhood acute lymphoblastic leukemia survivors: a tertiary center experience
title_sort serum endocan and endothelial dysfunction in childhood acute lymphoblastic leukemia survivors: a tertiary center experience
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155763/
https://www.ncbi.nlm.nih.gov/pubmed/34104378
http://dx.doi.org/10.1177/20406223211015963
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