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The Role of Viral Proteins in the Regulation of Exosomes Biogenesis
Exosomes are membrane-bound vesicles of endocytic origin, secreted into the extracellular milieu, in which various biological components such as proteins, nucleic acids, and lipids reside. A variety of external stimuli can regulate the formation and secretion of exosomes, including viruses. Viruses...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155792/ https://www.ncbi.nlm.nih.gov/pubmed/34055668 http://dx.doi.org/10.3389/fcimb.2021.671625 |
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author | Jia, Xiaonan Yin, Yiqian Chen, Yiwen Mao, Lingxiang |
author_facet | Jia, Xiaonan Yin, Yiqian Chen, Yiwen Mao, Lingxiang |
author_sort | Jia, Xiaonan |
collection | PubMed |
description | Exosomes are membrane-bound vesicles of endocytic origin, secreted into the extracellular milieu, in which various biological components such as proteins, nucleic acids, and lipids reside. A variety of external stimuli can regulate the formation and secretion of exosomes, including viruses. Viruses have evolved clever strategies to establish effective infections by employing exosomes to cloak their viral genomes and gain entry into uninfected cells. While most recent exosomal studies have focused on clarifying the effect of these bioactive vesicles on viral infection, the mechanisms by which the virus regulates exosomes are still unclear and deserve further attention. This article is devoted to studying how viral components regulate exosomes biogenesis, composition, and secretion. |
format | Online Article Text |
id | pubmed-8155792 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81557922021-05-28 The Role of Viral Proteins in the Regulation of Exosomes Biogenesis Jia, Xiaonan Yin, Yiqian Chen, Yiwen Mao, Lingxiang Front Cell Infect Microbiol Cellular and Infection Microbiology Exosomes are membrane-bound vesicles of endocytic origin, secreted into the extracellular milieu, in which various biological components such as proteins, nucleic acids, and lipids reside. A variety of external stimuli can regulate the formation and secretion of exosomes, including viruses. Viruses have evolved clever strategies to establish effective infections by employing exosomes to cloak their viral genomes and gain entry into uninfected cells. While most recent exosomal studies have focused on clarifying the effect of these bioactive vesicles on viral infection, the mechanisms by which the virus regulates exosomes are still unclear and deserve further attention. This article is devoted to studying how viral components regulate exosomes biogenesis, composition, and secretion. Frontiers Media S.A. 2021-05-13 /pmc/articles/PMC8155792/ /pubmed/34055668 http://dx.doi.org/10.3389/fcimb.2021.671625 Text en Copyright © 2021 Jia, Yin, Chen and Mao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Jia, Xiaonan Yin, Yiqian Chen, Yiwen Mao, Lingxiang The Role of Viral Proteins in the Regulation of Exosomes Biogenesis |
title | The Role of Viral Proteins in the Regulation of Exosomes Biogenesis |
title_full | The Role of Viral Proteins in the Regulation of Exosomes Biogenesis |
title_fullStr | The Role of Viral Proteins in the Regulation of Exosomes Biogenesis |
title_full_unstemmed | The Role of Viral Proteins in the Regulation of Exosomes Biogenesis |
title_short | The Role of Viral Proteins in the Regulation of Exosomes Biogenesis |
title_sort | role of viral proteins in the regulation of exosomes biogenesis |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155792/ https://www.ncbi.nlm.nih.gov/pubmed/34055668 http://dx.doi.org/10.3389/fcimb.2021.671625 |
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