Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate

The TREK subfamily of two-pore domain K(+) (K2P) channels are inhibited by fluoxetine and its metabolite, norfluoxetine (NFx). Although not the principal targets of this antidepressant, TREK channel inhibition by NFx has provided important insights into the conformational changes associated with cha...

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Detalles Bibliográficos
Autores principales: Proks, Peter, Schewe, Marcus, Conrad, Linus J., Rao, Shanlin, Rathje, Kristin, Rödström, Karin E.J., Carpenter, Elisabeth P., Baukrowitz, Thomas, Tucker, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155809/
https://www.ncbi.nlm.nih.gov/pubmed/34032848
http://dx.doi.org/10.1085/jgp.202012812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155809/
https://www.ncbi.nlm.nih.gov/pubmed/34032848
http://dx.doi.org/10.1085/jgp.202012812

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