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Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases

There has been an increasing prevalence of neurodegenerative diseases with the rapid increase in aging societies worldwide. Biomarkers that can be used to detect pathological changes before the development of severe neuronal loss and consequently facilitate early intervention with disease-modifying...

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Autores principales: Kamagata, Koji, Andica, Christina, Kato, Ayumi, Saito, Yuya, Uchida, Wataru, Hatano, Taku, Lukies, Matthew, Ogawa, Takashi, Takeshige-Amano, Haruka, Akashi, Toshiaki, Hagiwara, Akifumi, Fujita, Shohei, Aoki, Shigeki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155849/
https://www.ncbi.nlm.nih.gov/pubmed/34069159
http://dx.doi.org/10.3390/ijms22105216
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author Kamagata, Koji
Andica, Christina
Kato, Ayumi
Saito, Yuya
Uchida, Wataru
Hatano, Taku
Lukies, Matthew
Ogawa, Takashi
Takeshige-Amano, Haruka
Akashi, Toshiaki
Hagiwara, Akifumi
Fujita, Shohei
Aoki, Shigeki
author_facet Kamagata, Koji
Andica, Christina
Kato, Ayumi
Saito, Yuya
Uchida, Wataru
Hatano, Taku
Lukies, Matthew
Ogawa, Takashi
Takeshige-Amano, Haruka
Akashi, Toshiaki
Hagiwara, Akifumi
Fujita, Shohei
Aoki, Shigeki
author_sort Kamagata, Koji
collection PubMed
description There has been an increasing prevalence of neurodegenerative diseases with the rapid increase in aging societies worldwide. Biomarkers that can be used to detect pathological changes before the development of severe neuronal loss and consequently facilitate early intervention with disease-modifying therapeutic modalities are therefore urgently needed. Diffusion magnetic resonance imaging (MRI) is a promising tool that can be used to infer microstructural characteristics of the brain, such as microstructural integrity and complexity, as well as axonal density, order, and myelination, through the utilization of water molecules that are diffused within the tissue, with displacement at the micron scale. Diffusion tensor imaging is the most commonly used diffusion MRI technique to assess the pathophysiology of neurodegenerative diseases. However, diffusion tensor imaging has several limitations, and new technologies, including neurite orientation dispersion and density imaging, diffusion kurtosis imaging, and free-water imaging, have been recently developed as approaches to overcome these constraints. This review provides an overview of these technologies and their potential as biomarkers for the early diagnosis and disease progression of major neurodegenerative diseases.
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spelling pubmed-81558492021-05-28 Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases Kamagata, Koji Andica, Christina Kato, Ayumi Saito, Yuya Uchida, Wataru Hatano, Taku Lukies, Matthew Ogawa, Takashi Takeshige-Amano, Haruka Akashi, Toshiaki Hagiwara, Akifumi Fujita, Shohei Aoki, Shigeki Int J Mol Sci Review There has been an increasing prevalence of neurodegenerative diseases with the rapid increase in aging societies worldwide. Biomarkers that can be used to detect pathological changes before the development of severe neuronal loss and consequently facilitate early intervention with disease-modifying therapeutic modalities are therefore urgently needed. Diffusion magnetic resonance imaging (MRI) is a promising tool that can be used to infer microstructural characteristics of the brain, such as microstructural integrity and complexity, as well as axonal density, order, and myelination, through the utilization of water molecules that are diffused within the tissue, with displacement at the micron scale. Diffusion tensor imaging is the most commonly used diffusion MRI technique to assess the pathophysiology of neurodegenerative diseases. However, diffusion tensor imaging has several limitations, and new technologies, including neurite orientation dispersion and density imaging, diffusion kurtosis imaging, and free-water imaging, have been recently developed as approaches to overcome these constraints. This review provides an overview of these technologies and their potential as biomarkers for the early diagnosis and disease progression of major neurodegenerative diseases. MDPI 2021-05-14 /pmc/articles/PMC8155849/ /pubmed/34069159 http://dx.doi.org/10.3390/ijms22105216 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kamagata, Koji
Andica, Christina
Kato, Ayumi
Saito, Yuya
Uchida, Wataru
Hatano, Taku
Lukies, Matthew
Ogawa, Takashi
Takeshige-Amano, Haruka
Akashi, Toshiaki
Hagiwara, Akifumi
Fujita, Shohei
Aoki, Shigeki
Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases
title Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases
title_full Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases
title_fullStr Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases
title_full_unstemmed Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases
title_short Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases
title_sort diffusion magnetic resonance imaging-based biomarkers for neurodegenerative diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155849/
https://www.ncbi.nlm.nih.gov/pubmed/34069159
http://dx.doi.org/10.3390/ijms22105216
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