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Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases
There has been an increasing prevalence of neurodegenerative diseases with the rapid increase in aging societies worldwide. Biomarkers that can be used to detect pathological changes before the development of severe neuronal loss and consequently facilitate early intervention with disease-modifying...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155849/ https://www.ncbi.nlm.nih.gov/pubmed/34069159 http://dx.doi.org/10.3390/ijms22105216 |
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author | Kamagata, Koji Andica, Christina Kato, Ayumi Saito, Yuya Uchida, Wataru Hatano, Taku Lukies, Matthew Ogawa, Takashi Takeshige-Amano, Haruka Akashi, Toshiaki Hagiwara, Akifumi Fujita, Shohei Aoki, Shigeki |
author_facet | Kamagata, Koji Andica, Christina Kato, Ayumi Saito, Yuya Uchida, Wataru Hatano, Taku Lukies, Matthew Ogawa, Takashi Takeshige-Amano, Haruka Akashi, Toshiaki Hagiwara, Akifumi Fujita, Shohei Aoki, Shigeki |
author_sort | Kamagata, Koji |
collection | PubMed |
description | There has been an increasing prevalence of neurodegenerative diseases with the rapid increase in aging societies worldwide. Biomarkers that can be used to detect pathological changes before the development of severe neuronal loss and consequently facilitate early intervention with disease-modifying therapeutic modalities are therefore urgently needed. Diffusion magnetic resonance imaging (MRI) is a promising tool that can be used to infer microstructural characteristics of the brain, such as microstructural integrity and complexity, as well as axonal density, order, and myelination, through the utilization of water molecules that are diffused within the tissue, with displacement at the micron scale. Diffusion tensor imaging is the most commonly used diffusion MRI technique to assess the pathophysiology of neurodegenerative diseases. However, diffusion tensor imaging has several limitations, and new technologies, including neurite orientation dispersion and density imaging, diffusion kurtosis imaging, and free-water imaging, have been recently developed as approaches to overcome these constraints. This review provides an overview of these technologies and their potential as biomarkers for the early diagnosis and disease progression of major neurodegenerative diseases. |
format | Online Article Text |
id | pubmed-8155849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81558492021-05-28 Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases Kamagata, Koji Andica, Christina Kato, Ayumi Saito, Yuya Uchida, Wataru Hatano, Taku Lukies, Matthew Ogawa, Takashi Takeshige-Amano, Haruka Akashi, Toshiaki Hagiwara, Akifumi Fujita, Shohei Aoki, Shigeki Int J Mol Sci Review There has been an increasing prevalence of neurodegenerative diseases with the rapid increase in aging societies worldwide. Biomarkers that can be used to detect pathological changes before the development of severe neuronal loss and consequently facilitate early intervention with disease-modifying therapeutic modalities are therefore urgently needed. Diffusion magnetic resonance imaging (MRI) is a promising tool that can be used to infer microstructural characteristics of the brain, such as microstructural integrity and complexity, as well as axonal density, order, and myelination, through the utilization of water molecules that are diffused within the tissue, with displacement at the micron scale. Diffusion tensor imaging is the most commonly used diffusion MRI technique to assess the pathophysiology of neurodegenerative diseases. However, diffusion tensor imaging has several limitations, and new technologies, including neurite orientation dispersion and density imaging, diffusion kurtosis imaging, and free-water imaging, have been recently developed as approaches to overcome these constraints. This review provides an overview of these technologies and their potential as biomarkers for the early diagnosis and disease progression of major neurodegenerative diseases. MDPI 2021-05-14 /pmc/articles/PMC8155849/ /pubmed/34069159 http://dx.doi.org/10.3390/ijms22105216 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kamagata, Koji Andica, Christina Kato, Ayumi Saito, Yuya Uchida, Wataru Hatano, Taku Lukies, Matthew Ogawa, Takashi Takeshige-Amano, Haruka Akashi, Toshiaki Hagiwara, Akifumi Fujita, Shohei Aoki, Shigeki Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases |
title | Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases |
title_full | Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases |
title_fullStr | Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases |
title_full_unstemmed | Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases |
title_short | Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases |
title_sort | diffusion magnetic resonance imaging-based biomarkers for neurodegenerative diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155849/ https://www.ncbi.nlm.nih.gov/pubmed/34069159 http://dx.doi.org/10.3390/ijms22105216 |
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