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The Impact of the “Osteo” Component of Osteosarcopenia on Fragility Fractures in Post-Menopausal Women

Osteosarcopenia, the coexistence of bone and muscle loss, is common in older adults, but its definition lacks international consensus. This cross-sectional study (n = 1199 post-menopausal women) aimed to determine the association between osteosarcopenia and fragility fractures and to investigate the...

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Autores principales: Lin, Yen-Huai, Shih, Yu-Tai, Teng, Michael Mu Huo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155869/
https://www.ncbi.nlm.nih.gov/pubmed/34067582
http://dx.doi.org/10.3390/ijms22105256
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author Lin, Yen-Huai
Shih, Yu-Tai
Teng, Michael Mu Huo
author_facet Lin, Yen-Huai
Shih, Yu-Tai
Teng, Michael Mu Huo
author_sort Lin, Yen-Huai
collection PubMed
description Osteosarcopenia, the coexistence of bone and muscle loss, is common in older adults, but its definition lacks international consensus. This cross-sectional study (n = 1199 post-menopausal women) aimed to determine the association between osteosarcopenia and fragility fractures and to investigate the impact of the definition of the “osteo” component. Bone mineral density and bone microarchitecture were measured by dual-energy X-ray absorptiometry and the trabecular bone score (TBS), respectively. The “osteo” component of osteosarcopenia was classified as osteoporosis (T-score ≤ −2.5 SD), osteopenia/osteoporosis (T-score < −1 SD), and high-fracture-risk osteopenia (−2.5 SD < T-score < −1 SD)/osteoporosis (T-score ≤ −2.5 SD). The Fracture Risk Assessment Tool was used to identify high-fracture-risk osteopenia. Altogether, 30.3%, 32.2%, 14.4%, and 23.1% of participants had osteosarcopenia, osteoporosis alone, sarcopenia alone, and neither condition, respectively. The odds ratios between osteosarcopenia and fragility fractures were 3.70 (95% CI: 1.94–7.04) for osteosarcopenia, 2.48 (95% CI: 1.30–4.71) for osteoporosis alone, and 1.87 (95% CI: 0.84–4.14) for sarcopenia alone. Women with osteosarcopenia also had lower TBS, indicating worse bone microarchitecture. In conclusion, women with osteosarcopenia were more likely to have previously sustained a fracture compared to those without osteosarcopenia, with sarcopenia alone, and with osteoporosis alone. The relationship between osteosarcopenia and fracture risk may be best identified when considering high-fracture-risk osteopenia and osteoporosis.
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spelling pubmed-81558692021-05-28 The Impact of the “Osteo” Component of Osteosarcopenia on Fragility Fractures in Post-Menopausal Women Lin, Yen-Huai Shih, Yu-Tai Teng, Michael Mu Huo Int J Mol Sci Article Osteosarcopenia, the coexistence of bone and muscle loss, is common in older adults, but its definition lacks international consensus. This cross-sectional study (n = 1199 post-menopausal women) aimed to determine the association between osteosarcopenia and fragility fractures and to investigate the impact of the definition of the “osteo” component. Bone mineral density and bone microarchitecture were measured by dual-energy X-ray absorptiometry and the trabecular bone score (TBS), respectively. The “osteo” component of osteosarcopenia was classified as osteoporosis (T-score ≤ −2.5 SD), osteopenia/osteoporosis (T-score < −1 SD), and high-fracture-risk osteopenia (−2.5 SD < T-score < −1 SD)/osteoporosis (T-score ≤ −2.5 SD). The Fracture Risk Assessment Tool was used to identify high-fracture-risk osteopenia. Altogether, 30.3%, 32.2%, 14.4%, and 23.1% of participants had osteosarcopenia, osteoporosis alone, sarcopenia alone, and neither condition, respectively. The odds ratios between osteosarcopenia and fragility fractures were 3.70 (95% CI: 1.94–7.04) for osteosarcopenia, 2.48 (95% CI: 1.30–4.71) for osteoporosis alone, and 1.87 (95% CI: 0.84–4.14) for sarcopenia alone. Women with osteosarcopenia also had lower TBS, indicating worse bone microarchitecture. In conclusion, women with osteosarcopenia were more likely to have previously sustained a fracture compared to those without osteosarcopenia, with sarcopenia alone, and with osteoporosis alone. The relationship between osteosarcopenia and fracture risk may be best identified when considering high-fracture-risk osteopenia and osteoporosis. MDPI 2021-05-17 /pmc/articles/PMC8155869/ /pubmed/34067582 http://dx.doi.org/10.3390/ijms22105256 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Yen-Huai
Shih, Yu-Tai
Teng, Michael Mu Huo
The Impact of the “Osteo” Component of Osteosarcopenia on Fragility Fractures in Post-Menopausal Women
title The Impact of the “Osteo” Component of Osteosarcopenia on Fragility Fractures in Post-Menopausal Women
title_full The Impact of the “Osteo” Component of Osteosarcopenia on Fragility Fractures in Post-Menopausal Women
title_fullStr The Impact of the “Osteo” Component of Osteosarcopenia on Fragility Fractures in Post-Menopausal Women
title_full_unstemmed The Impact of the “Osteo” Component of Osteosarcopenia on Fragility Fractures in Post-Menopausal Women
title_short The Impact of the “Osteo” Component of Osteosarcopenia on Fragility Fractures in Post-Menopausal Women
title_sort impact of the “osteo” component of osteosarcopenia on fragility fractures in post-menopausal women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155869/
https://www.ncbi.nlm.nih.gov/pubmed/34067582
http://dx.doi.org/10.3390/ijms22105256
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