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Presepsin in the Rapid Response System for Cancer Patients: A Retrospective Analysis

Introduction: Early diagnosis of sepsis is paramount to effective management. The present study aimed to compare the prognostic accuracy of presepsin levels and other biomarkers in the assessment of septic shock and mortality risk in cancer patients. Materials and methods: A total of 74 cancer patie...

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Autores principales: Lee, Min-Jung, Han, Won-Ho, Chun, June-Young, Kim, Sun-Young, Kim, Jee-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155948/
https://www.ncbi.nlm.nih.gov/pubmed/34065685
http://dx.doi.org/10.3390/jcm10102153
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author Lee, Min-Jung
Han, Won-Ho
Chun, June-Young
Kim, Sun-Young
Kim, Jee-Hee
author_facet Lee, Min-Jung
Han, Won-Ho
Chun, June-Young
Kim, Sun-Young
Kim, Jee-Hee
author_sort Lee, Min-Jung
collection PubMed
description Introduction: Early diagnosis of sepsis is paramount to effective management. The present study aimed to compare the prognostic accuracy of presepsin levels and other biomarkers in the assessment of septic shock and mortality risk in cancer patients. Materials and methods: A total of 74 cancer patients were evaluated for presepsin, lactic acid, C-reactive protein (CRP) levels, and white blood cell count (WBC). Specificity and sensitivity values for septic shock and death were compared between four biomarkers in all patients and those with and without acute kidney injury (AKI). Results: A total of 27 and 29 patients experienced septic shock and died, respectively. The area under the curve (AUC) and sensitivity and specificity estimated for presepsin levels for septic shock were 60%, 74%, and 51%, respectively. The corresponding values for mortality were 62%, 72%, and 49%, respectively. In patients without AKI, AUC of presepsin levels for septic shock and death were 62% and 65%, respectively; in those with AKI, these values were 44% and 58%, respectively. Presepsin levels showed higher sensitivity and specificity values than WBC and higher specificity than CRP but were similar to those of lactic acid levels. Conclusions: Presepsin levels are similar to lactic acid levels in the assessment of septic shock and mortality risk in cancer patients. In patients with AKI, presepsin levels should be considered carefully.
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spelling pubmed-81559482021-05-28 Presepsin in the Rapid Response System for Cancer Patients: A Retrospective Analysis Lee, Min-Jung Han, Won-Ho Chun, June-Young Kim, Sun-Young Kim, Jee-Hee J Clin Med Article Introduction: Early diagnosis of sepsis is paramount to effective management. The present study aimed to compare the prognostic accuracy of presepsin levels and other biomarkers in the assessment of septic shock and mortality risk in cancer patients. Materials and methods: A total of 74 cancer patients were evaluated for presepsin, lactic acid, C-reactive protein (CRP) levels, and white blood cell count (WBC). Specificity and sensitivity values for septic shock and death were compared between four biomarkers in all patients and those with and without acute kidney injury (AKI). Results: A total of 27 and 29 patients experienced septic shock and died, respectively. The area under the curve (AUC) and sensitivity and specificity estimated for presepsin levels for septic shock were 60%, 74%, and 51%, respectively. The corresponding values for mortality were 62%, 72%, and 49%, respectively. In patients without AKI, AUC of presepsin levels for septic shock and death were 62% and 65%, respectively; in those with AKI, these values were 44% and 58%, respectively. Presepsin levels showed higher sensitivity and specificity values than WBC and higher specificity than CRP but were similar to those of lactic acid levels. Conclusions: Presepsin levels are similar to lactic acid levels in the assessment of septic shock and mortality risk in cancer patients. In patients with AKI, presepsin levels should be considered carefully. MDPI 2021-05-16 /pmc/articles/PMC8155948/ /pubmed/34065685 http://dx.doi.org/10.3390/jcm10102153 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Min-Jung
Han, Won-Ho
Chun, June-Young
Kim, Sun-Young
Kim, Jee-Hee
Presepsin in the Rapid Response System for Cancer Patients: A Retrospective Analysis
title Presepsin in the Rapid Response System for Cancer Patients: A Retrospective Analysis
title_full Presepsin in the Rapid Response System for Cancer Patients: A Retrospective Analysis
title_fullStr Presepsin in the Rapid Response System for Cancer Patients: A Retrospective Analysis
title_full_unstemmed Presepsin in the Rapid Response System for Cancer Patients: A Retrospective Analysis
title_short Presepsin in the Rapid Response System for Cancer Patients: A Retrospective Analysis
title_sort presepsin in the rapid response system for cancer patients: a retrospective analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155948/
https://www.ncbi.nlm.nih.gov/pubmed/34065685
http://dx.doi.org/10.3390/jcm10102153
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