Cargando…

Hematopoietic Stem Cells: Nature and Niche Nurture

Like all cells, hematopoietic stem cells (HSCs) and their offspring, the hematopoietic progenitor cells (HPCs), are highly sociable. Their capacity to interact with bone marrow niche cells and respond to environmental cytokines orchestrates the generation of the different types of blood and immune c...

Descripción completa

Detalles Bibliográficos
Autor principal: Brown, Geoffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155961/
https://www.ncbi.nlm.nih.gov/pubmed/34063400
http://dx.doi.org/10.3390/bioengineering8050067
_version_ 1783699326129668096
author Brown, Geoffrey
author_facet Brown, Geoffrey
author_sort Brown, Geoffrey
collection PubMed
description Like all cells, hematopoietic stem cells (HSCs) and their offspring, the hematopoietic progenitor cells (HPCs), are highly sociable. Their capacity to interact with bone marrow niche cells and respond to environmental cytokines orchestrates the generation of the different types of blood and immune cells. The starting point for engineering hematopoiesis ex vivo is the nature of HSCs, and a longstanding premise is that they are a homogeneous population of cells. However, recent findings have shown that adult bone marrow HSCs are really a mixture of cells, with many having lineage affiliations. A second key consideration is: Do HSCs “choose” a lineage in a random and cell-intrinsic manner, or are they instructed by cytokines? Since their discovery, the hematopoietic cytokines have been viewed as survival and proliferation factors for lineage committed HPCs. Some are now known to also instruct cell lineage choice. These fundamental changes to our understanding of hematopoiesis are important for placing niche support in the right context and for fabricating an ex vivo environment to support HSC development.
format Online
Article
Text
id pubmed-8155961
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81559612021-05-28 Hematopoietic Stem Cells: Nature and Niche Nurture Brown, Geoffrey Bioengineering (Basel) Review Like all cells, hematopoietic stem cells (HSCs) and their offspring, the hematopoietic progenitor cells (HPCs), are highly sociable. Their capacity to interact with bone marrow niche cells and respond to environmental cytokines orchestrates the generation of the different types of blood and immune cells. The starting point for engineering hematopoiesis ex vivo is the nature of HSCs, and a longstanding premise is that they are a homogeneous population of cells. However, recent findings have shown that adult bone marrow HSCs are really a mixture of cells, with many having lineage affiliations. A second key consideration is: Do HSCs “choose” a lineage in a random and cell-intrinsic manner, or are they instructed by cytokines? Since their discovery, the hematopoietic cytokines have been viewed as survival and proliferation factors for lineage committed HPCs. Some are now known to also instruct cell lineage choice. These fundamental changes to our understanding of hematopoiesis are important for placing niche support in the right context and for fabricating an ex vivo environment to support HSC development. MDPI 2021-05-15 /pmc/articles/PMC8155961/ /pubmed/34063400 http://dx.doi.org/10.3390/bioengineering8050067 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Brown, Geoffrey
Hematopoietic Stem Cells: Nature and Niche Nurture
title Hematopoietic Stem Cells: Nature and Niche Nurture
title_full Hematopoietic Stem Cells: Nature and Niche Nurture
title_fullStr Hematopoietic Stem Cells: Nature and Niche Nurture
title_full_unstemmed Hematopoietic Stem Cells: Nature and Niche Nurture
title_short Hematopoietic Stem Cells: Nature and Niche Nurture
title_sort hematopoietic stem cells: nature and niche nurture
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155961/
https://www.ncbi.nlm.nih.gov/pubmed/34063400
http://dx.doi.org/10.3390/bioengineering8050067
work_keys_str_mv AT browngeoffrey hematopoieticstemcellsnatureandnichenurture