Cargando…
Hematopoietic Stem Cells: Nature and Niche Nurture
Like all cells, hematopoietic stem cells (HSCs) and their offspring, the hematopoietic progenitor cells (HPCs), are highly sociable. Their capacity to interact with bone marrow niche cells and respond to environmental cytokines orchestrates the generation of the different types of blood and immune c...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155961/ https://www.ncbi.nlm.nih.gov/pubmed/34063400 http://dx.doi.org/10.3390/bioengineering8050067 |
_version_ | 1783699326129668096 |
---|---|
author | Brown, Geoffrey |
author_facet | Brown, Geoffrey |
author_sort | Brown, Geoffrey |
collection | PubMed |
description | Like all cells, hematopoietic stem cells (HSCs) and their offspring, the hematopoietic progenitor cells (HPCs), are highly sociable. Their capacity to interact with bone marrow niche cells and respond to environmental cytokines orchestrates the generation of the different types of blood and immune cells. The starting point for engineering hematopoiesis ex vivo is the nature of HSCs, and a longstanding premise is that they are a homogeneous population of cells. However, recent findings have shown that adult bone marrow HSCs are really a mixture of cells, with many having lineage affiliations. A second key consideration is: Do HSCs “choose” a lineage in a random and cell-intrinsic manner, or are they instructed by cytokines? Since their discovery, the hematopoietic cytokines have been viewed as survival and proliferation factors for lineage committed HPCs. Some are now known to also instruct cell lineage choice. These fundamental changes to our understanding of hematopoiesis are important for placing niche support in the right context and for fabricating an ex vivo environment to support HSC development. |
format | Online Article Text |
id | pubmed-8155961 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81559612021-05-28 Hematopoietic Stem Cells: Nature and Niche Nurture Brown, Geoffrey Bioengineering (Basel) Review Like all cells, hematopoietic stem cells (HSCs) and their offspring, the hematopoietic progenitor cells (HPCs), are highly sociable. Their capacity to interact with bone marrow niche cells and respond to environmental cytokines orchestrates the generation of the different types of blood and immune cells. The starting point for engineering hematopoiesis ex vivo is the nature of HSCs, and a longstanding premise is that they are a homogeneous population of cells. However, recent findings have shown that adult bone marrow HSCs are really a mixture of cells, with many having lineage affiliations. A second key consideration is: Do HSCs “choose” a lineage in a random and cell-intrinsic manner, or are they instructed by cytokines? Since their discovery, the hematopoietic cytokines have been viewed as survival and proliferation factors for lineage committed HPCs. Some are now known to also instruct cell lineage choice. These fundamental changes to our understanding of hematopoiesis are important for placing niche support in the right context and for fabricating an ex vivo environment to support HSC development. MDPI 2021-05-15 /pmc/articles/PMC8155961/ /pubmed/34063400 http://dx.doi.org/10.3390/bioengineering8050067 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Brown, Geoffrey Hematopoietic Stem Cells: Nature and Niche Nurture |
title | Hematopoietic Stem Cells: Nature and Niche Nurture |
title_full | Hematopoietic Stem Cells: Nature and Niche Nurture |
title_fullStr | Hematopoietic Stem Cells: Nature and Niche Nurture |
title_full_unstemmed | Hematopoietic Stem Cells: Nature and Niche Nurture |
title_short | Hematopoietic Stem Cells: Nature and Niche Nurture |
title_sort | hematopoietic stem cells: nature and niche nurture |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155961/ https://www.ncbi.nlm.nih.gov/pubmed/34063400 http://dx.doi.org/10.3390/bioengineering8050067 |
work_keys_str_mv | AT browngeoffrey hematopoieticstemcellsnatureandnichenurture |