High Flexibility of RNaseH2 Catalytic Activity with Respect to Non-Canonical DNA Structures

Ribonucleotides misincorporated in the human genome are the most abundant DNA lesions. The 2′-hydroxyl group makes them prone to spontaneous hydrolysis, potentially resulting in strand breaks. Moreover, their presence may decrease the rate of DNA replication causing replicative fork stalling and col...

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Detalles Bibliográficos
Autores principales: Dede, Maria, Napolitano, Silvia, Melati, Anna, Pirota, Valentina, Maga, Giovanni, Crespan, Emmanuele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155979/
https://www.ncbi.nlm.nih.gov/pubmed/34068992
http://dx.doi.org/10.3390/ijms22105201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155979/
https://www.ncbi.nlm.nih.gov/pubmed/34068992
http://dx.doi.org/10.3390/ijms22105201

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