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Predictive Relevance of Baseline Lactate and Glucose Levels in Patients with Spontaneous Deep-Seated Intracerebral Hemorrhage

(1) Background: As elements of the standard admission blood panel, lactate and glucose represent potential biomarkers for outcome prediction. In patients with intracranial hemorrhage (ICH), data on the predictive value of these blood values is exceedingly sparse. (2) Methods: Between 2014 and August...

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Autores principales: Lehmann, Felix, Schenk, Lorena M., Schneider, Matthias, Bernstock, Joshua D., Bode, Christian, Borger, Valeri, Gessler, Florian, Güresir, Erdem, Hadjiathanasiou, Alexis, Hamed, Motaz, Müller, Marcus, Putensen, Christian, Zimmermann, Julian, Vatter, Hartmut, Schuss, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156008/
https://www.ncbi.nlm.nih.gov/pubmed/34069048
http://dx.doi.org/10.3390/brainsci11050633
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author Lehmann, Felix
Schenk, Lorena M.
Schneider, Matthias
Bernstock, Joshua D.
Bode, Christian
Borger, Valeri
Gessler, Florian
Güresir, Erdem
Hadjiathanasiou, Alexis
Hamed, Motaz
Müller, Marcus
Putensen, Christian
Zimmermann, Julian
Vatter, Hartmut
Schuss, Patrick
author_facet Lehmann, Felix
Schenk, Lorena M.
Schneider, Matthias
Bernstock, Joshua D.
Bode, Christian
Borger, Valeri
Gessler, Florian
Güresir, Erdem
Hadjiathanasiou, Alexis
Hamed, Motaz
Müller, Marcus
Putensen, Christian
Zimmermann, Julian
Vatter, Hartmut
Schuss, Patrick
author_sort Lehmann, Felix
collection PubMed
description (1) Background: As elements of the standard admission blood panel, lactate and glucose represent potential biomarkers for outcome prediction. In patients with intracranial hemorrhage (ICH), data on the predictive value of these blood values is exceedingly sparse. (2) Methods: Between 2014 and August 2020, all patients with deep-seated ICH referred to the neurovascular center at the authors’ institution were included in the subsequent study. Serum levels of lactate and glucose at the time of admission were compared with mortality at 90 days. In addition, a multivariate analysis was performed in order to identify independent admission predictors for 90-day mortality. (3) Results: Among the 102 patients with deep-seated ICH, elevated lactate and glucose levels on admission were significantly associated with increased mortality at 90 days. Multivariate logistic regression analysis identified “ICH score ≥3” (p = 0.004) along with “admission hyperlactatemia” (p = 0.025) and “admission hyperglycemia” (p = 0.029) as independent and significant predictors of 90-day mortality in patients with deep-seated ICH. (4) Conclusions: Initially elevated lactate and glucose levels after spontaneous intracerebral hemorrhage are associated with poor outcome, suggesting a potential application for future prognostic models when considered in conjunction with other parameters.
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spelling pubmed-81560082021-05-28 Predictive Relevance of Baseline Lactate and Glucose Levels in Patients with Spontaneous Deep-Seated Intracerebral Hemorrhage Lehmann, Felix Schenk, Lorena M. Schneider, Matthias Bernstock, Joshua D. Bode, Christian Borger, Valeri Gessler, Florian Güresir, Erdem Hadjiathanasiou, Alexis Hamed, Motaz Müller, Marcus Putensen, Christian Zimmermann, Julian Vatter, Hartmut Schuss, Patrick Brain Sci Article (1) Background: As elements of the standard admission blood panel, lactate and glucose represent potential biomarkers for outcome prediction. In patients with intracranial hemorrhage (ICH), data on the predictive value of these blood values is exceedingly sparse. (2) Methods: Between 2014 and August 2020, all patients with deep-seated ICH referred to the neurovascular center at the authors’ institution were included in the subsequent study. Serum levels of lactate and glucose at the time of admission were compared with mortality at 90 days. In addition, a multivariate analysis was performed in order to identify independent admission predictors for 90-day mortality. (3) Results: Among the 102 patients with deep-seated ICH, elevated lactate and glucose levels on admission were significantly associated with increased mortality at 90 days. Multivariate logistic regression analysis identified “ICH score ≥3” (p = 0.004) along with “admission hyperlactatemia” (p = 0.025) and “admission hyperglycemia” (p = 0.029) as independent and significant predictors of 90-day mortality in patients with deep-seated ICH. (4) Conclusions: Initially elevated lactate and glucose levels after spontaneous intracerebral hemorrhage are associated with poor outcome, suggesting a potential application for future prognostic models when considered in conjunction with other parameters. MDPI 2021-05-14 /pmc/articles/PMC8156008/ /pubmed/34069048 http://dx.doi.org/10.3390/brainsci11050633 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lehmann, Felix
Schenk, Lorena M.
Schneider, Matthias
Bernstock, Joshua D.
Bode, Christian
Borger, Valeri
Gessler, Florian
Güresir, Erdem
Hadjiathanasiou, Alexis
Hamed, Motaz
Müller, Marcus
Putensen, Christian
Zimmermann, Julian
Vatter, Hartmut
Schuss, Patrick
Predictive Relevance of Baseline Lactate and Glucose Levels in Patients with Spontaneous Deep-Seated Intracerebral Hemorrhage
title Predictive Relevance of Baseline Lactate and Glucose Levels in Patients with Spontaneous Deep-Seated Intracerebral Hemorrhage
title_full Predictive Relevance of Baseline Lactate and Glucose Levels in Patients with Spontaneous Deep-Seated Intracerebral Hemorrhage
title_fullStr Predictive Relevance of Baseline Lactate and Glucose Levels in Patients with Spontaneous Deep-Seated Intracerebral Hemorrhage
title_full_unstemmed Predictive Relevance of Baseline Lactate and Glucose Levels in Patients with Spontaneous Deep-Seated Intracerebral Hemorrhage
title_short Predictive Relevance of Baseline Lactate and Glucose Levels in Patients with Spontaneous Deep-Seated Intracerebral Hemorrhage
title_sort predictive relevance of baseline lactate and glucose levels in patients with spontaneous deep-seated intracerebral hemorrhage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156008/
https://www.ncbi.nlm.nih.gov/pubmed/34069048
http://dx.doi.org/10.3390/brainsci11050633
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