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Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease

The applications of 3D bioprinting are becoming more commonplace. Since the advent of tissue engineering, bone has received much attention for the ability to engineer normal bone for tissue engraftment or replacement. While there are still debates on what materials comprise the most durable and natu...

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Autores principales: Pavek, Adriene, Nartker, Christopher, Saleh, Maamoon, Kirkham, Matthew, Khajeh Pour, Sana, Aghazadeh-Habashi, Ali, Barrott, Jared J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156159/
https://www.ncbi.nlm.nih.gov/pubmed/34068971
http://dx.doi.org/10.3390/biomedicines9050551
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author Pavek, Adriene
Nartker, Christopher
Saleh, Maamoon
Kirkham, Matthew
Khajeh Pour, Sana
Aghazadeh-Habashi, Ali
Barrott, Jared J.
author_facet Pavek, Adriene
Nartker, Christopher
Saleh, Maamoon
Kirkham, Matthew
Khajeh Pour, Sana
Aghazadeh-Habashi, Ali
Barrott, Jared J.
author_sort Pavek, Adriene
collection PubMed
description The applications of 3D bioprinting are becoming more commonplace. Since the advent of tissue engineering, bone has received much attention for the ability to engineer normal bone for tissue engraftment or replacement. While there are still debates on what materials comprise the most durable and natural replacement of normal tissue, little attention is given to recreating diseased states within the bone. With a better understanding of the cellular pathophysiology associated with the more common bone diseases, these diseases can be scaled down to a more throughput way to test therapies that can reverse the cellular pathophysiology. In this review, we will discuss the potential of 3D bioprinting of bone tissue in the following disease states: osteoporosis, Paget’s disease, heterotopic ossification, osteosarcoma, osteogenesis imperfecta, and rickets disease. The development of these 3D bioprinted models will allow for the advancement of novel therapy testing resulting in possible relief to these chronic diseases.
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spelling pubmed-81561592021-05-28 Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease Pavek, Adriene Nartker, Christopher Saleh, Maamoon Kirkham, Matthew Khajeh Pour, Sana Aghazadeh-Habashi, Ali Barrott, Jared J. Biomedicines Review The applications of 3D bioprinting are becoming more commonplace. Since the advent of tissue engineering, bone has received much attention for the ability to engineer normal bone for tissue engraftment or replacement. While there are still debates on what materials comprise the most durable and natural replacement of normal tissue, little attention is given to recreating diseased states within the bone. With a better understanding of the cellular pathophysiology associated with the more common bone diseases, these diseases can be scaled down to a more throughput way to test therapies that can reverse the cellular pathophysiology. In this review, we will discuss the potential of 3D bioprinting of bone tissue in the following disease states: osteoporosis, Paget’s disease, heterotopic ossification, osteosarcoma, osteogenesis imperfecta, and rickets disease. The development of these 3D bioprinted models will allow for the advancement of novel therapy testing resulting in possible relief to these chronic diseases. MDPI 2021-05-14 /pmc/articles/PMC8156159/ /pubmed/34068971 http://dx.doi.org/10.3390/biomedicines9050551 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pavek, Adriene
Nartker, Christopher
Saleh, Maamoon
Kirkham, Matthew
Khajeh Pour, Sana
Aghazadeh-Habashi, Ali
Barrott, Jared J.
Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease
title Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease
title_full Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease
title_fullStr Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease
title_full_unstemmed Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease
title_short Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease
title_sort tissue engineering through 3d bioprinting to recreate and study bone disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156159/
https://www.ncbi.nlm.nih.gov/pubmed/34068971
http://dx.doi.org/10.3390/biomedicines9050551
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