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Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease
The applications of 3D bioprinting are becoming more commonplace. Since the advent of tissue engineering, bone has received much attention for the ability to engineer normal bone for tissue engraftment or replacement. While there are still debates on what materials comprise the most durable and natu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156159/ https://www.ncbi.nlm.nih.gov/pubmed/34068971 http://dx.doi.org/10.3390/biomedicines9050551 |
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author | Pavek, Adriene Nartker, Christopher Saleh, Maamoon Kirkham, Matthew Khajeh Pour, Sana Aghazadeh-Habashi, Ali Barrott, Jared J. |
author_facet | Pavek, Adriene Nartker, Christopher Saleh, Maamoon Kirkham, Matthew Khajeh Pour, Sana Aghazadeh-Habashi, Ali Barrott, Jared J. |
author_sort | Pavek, Adriene |
collection | PubMed |
description | The applications of 3D bioprinting are becoming more commonplace. Since the advent of tissue engineering, bone has received much attention for the ability to engineer normal bone for tissue engraftment or replacement. While there are still debates on what materials comprise the most durable and natural replacement of normal tissue, little attention is given to recreating diseased states within the bone. With a better understanding of the cellular pathophysiology associated with the more common bone diseases, these diseases can be scaled down to a more throughput way to test therapies that can reverse the cellular pathophysiology. In this review, we will discuss the potential of 3D bioprinting of bone tissue in the following disease states: osteoporosis, Paget’s disease, heterotopic ossification, osteosarcoma, osteogenesis imperfecta, and rickets disease. The development of these 3D bioprinted models will allow for the advancement of novel therapy testing resulting in possible relief to these chronic diseases. |
format | Online Article Text |
id | pubmed-8156159 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81561592021-05-28 Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease Pavek, Adriene Nartker, Christopher Saleh, Maamoon Kirkham, Matthew Khajeh Pour, Sana Aghazadeh-Habashi, Ali Barrott, Jared J. Biomedicines Review The applications of 3D bioprinting are becoming more commonplace. Since the advent of tissue engineering, bone has received much attention for the ability to engineer normal bone for tissue engraftment or replacement. While there are still debates on what materials comprise the most durable and natural replacement of normal tissue, little attention is given to recreating diseased states within the bone. With a better understanding of the cellular pathophysiology associated with the more common bone diseases, these diseases can be scaled down to a more throughput way to test therapies that can reverse the cellular pathophysiology. In this review, we will discuss the potential of 3D bioprinting of bone tissue in the following disease states: osteoporosis, Paget’s disease, heterotopic ossification, osteosarcoma, osteogenesis imperfecta, and rickets disease. The development of these 3D bioprinted models will allow for the advancement of novel therapy testing resulting in possible relief to these chronic diseases. MDPI 2021-05-14 /pmc/articles/PMC8156159/ /pubmed/34068971 http://dx.doi.org/10.3390/biomedicines9050551 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pavek, Adriene Nartker, Christopher Saleh, Maamoon Kirkham, Matthew Khajeh Pour, Sana Aghazadeh-Habashi, Ali Barrott, Jared J. Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease |
title | Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease |
title_full | Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease |
title_fullStr | Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease |
title_full_unstemmed | Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease |
title_short | Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease |
title_sort | tissue engineering through 3d bioprinting to recreate and study bone disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156159/ https://www.ncbi.nlm.nih.gov/pubmed/34068971 http://dx.doi.org/10.3390/biomedicines9050551 |
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