Direct Diagnosis of Echovirus 12 Meningitis Using Metagenomic Next Generation Sequencing

The current point-of-care diagnosis of enterovirus meningitis does not identify the viral genotype, which is prognostic. In this case report, more than 81% of an Echovirus 12 genome were detected and identified by metagenomic next-generation sequencing, directly from the cerebrospinal fluid collecte...

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Autores principales: Morsli, Madjid, Zandotti, Christine, Morand, Aurelie, Colson, Philippe, Drancourt, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156364/
https://www.ncbi.nlm.nih.gov/pubmed/34067526
http://dx.doi.org/10.3390/pathogens10050610
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author Morsli, Madjid
Zandotti, Christine
Morand, Aurelie
Colson, Philippe
Drancourt, Michel
author_facet Morsli, Madjid
Zandotti, Christine
Morand, Aurelie
Colson, Philippe
Drancourt, Michel
author_sort Morsli, Madjid
collection PubMed
description The current point-of-care diagnosis of enterovirus meningitis does not identify the viral genotype, which is prognostic. In this case report, more than 81% of an Echovirus 12 genome were detected and identified by metagenomic next-generation sequencing, directly from the cerebrospinal fluid collected in a 6-month-old child with meningeal syndrome and meningitis: introducing Echovirus 12 as an etiological agent of acute meningitis in the pediatric population.
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spelling pubmed-81563642021-05-28 Direct Diagnosis of Echovirus 12 Meningitis Using Metagenomic Next Generation Sequencing Morsli, Madjid Zandotti, Christine Morand, Aurelie Colson, Philippe Drancourt, Michel Pathogens Brief Report The current point-of-care diagnosis of enterovirus meningitis does not identify the viral genotype, which is prognostic. In this case report, more than 81% of an Echovirus 12 genome were detected and identified by metagenomic next-generation sequencing, directly from the cerebrospinal fluid collected in a 6-month-old child with meningeal syndrome and meningitis: introducing Echovirus 12 as an etiological agent of acute meningitis in the pediatric population. MDPI 2021-05-17 /pmc/articles/PMC8156364/ /pubmed/34067526 http://dx.doi.org/10.3390/pathogens10050610 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Morsli, Madjid
Zandotti, Christine
Morand, Aurelie
Colson, Philippe
Drancourt, Michel
Direct Diagnosis of Echovirus 12 Meningitis Using Metagenomic Next Generation Sequencing
title Direct Diagnosis of Echovirus 12 Meningitis Using Metagenomic Next Generation Sequencing
title_full Direct Diagnosis of Echovirus 12 Meningitis Using Metagenomic Next Generation Sequencing
title_fullStr Direct Diagnosis of Echovirus 12 Meningitis Using Metagenomic Next Generation Sequencing
title_full_unstemmed Direct Diagnosis of Echovirus 12 Meningitis Using Metagenomic Next Generation Sequencing
title_short Direct Diagnosis of Echovirus 12 Meningitis Using Metagenomic Next Generation Sequencing
title_sort direct diagnosis of echovirus 12 meningitis using metagenomic next generation sequencing
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156364/
https://www.ncbi.nlm.nih.gov/pubmed/34067526
http://dx.doi.org/10.3390/pathogens10050610
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