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Influenza- and COVID-19-Associated Pulmonary Aspergillosis: Are the Pictures Different?

Invasive pulmonary aspergillosis (IPA) in intensive care unit patients is a major concern. Influenza-associated acute respiratory distress syndrome (ARDS) and severe COVID-19 patients are both at risk of developing invasive fungal diseases. We used the new international definitions of influenza-asso...

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Autores principales: Reizine, Florian, Pinceaux, Kieran, Lederlin, Mathieu, Autier, Brice, Guegan, Hélène, Gacouin, Arnaud, Luque-Paz, David, Boglione-Kerrien, Christelle, Bacle, Astrid, Le Daré, Brendan, Launey, Yoann, Lesouhaitier, Mathieu, Painvin, Benoit, Camus, Christophe, Mansour, Alexandre, Robert-Gangneux, Florence, Belaz, Sorya, Le Tulzo, Yves, Tadié, Jean-Marc, Maamar, Adel, Gangneux, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156373/
https://www.ncbi.nlm.nih.gov/pubmed/34063556
http://dx.doi.org/10.3390/jof7050388
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author Reizine, Florian
Pinceaux, Kieran
Lederlin, Mathieu
Autier, Brice
Guegan, Hélène
Gacouin, Arnaud
Luque-Paz, David
Boglione-Kerrien, Christelle
Bacle, Astrid
Le Daré, Brendan
Launey, Yoann
Lesouhaitier, Mathieu
Painvin, Benoit
Camus, Christophe
Mansour, Alexandre
Robert-Gangneux, Florence
Belaz, Sorya
Le Tulzo, Yves
Tadié, Jean-Marc
Maamar, Adel
Gangneux, Jean-Pierre
author_facet Reizine, Florian
Pinceaux, Kieran
Lederlin, Mathieu
Autier, Brice
Guegan, Hélène
Gacouin, Arnaud
Luque-Paz, David
Boglione-Kerrien, Christelle
Bacle, Astrid
Le Daré, Brendan
Launey, Yoann
Lesouhaitier, Mathieu
Painvin, Benoit
Camus, Christophe
Mansour, Alexandre
Robert-Gangneux, Florence
Belaz, Sorya
Le Tulzo, Yves
Tadié, Jean-Marc
Maamar, Adel
Gangneux, Jean-Pierre
author_sort Reizine, Florian
collection PubMed
description Invasive pulmonary aspergillosis (IPA) in intensive care unit patients is a major concern. Influenza-associated acute respiratory distress syndrome (ARDS) and severe COVID-19 patients are both at risk of developing invasive fungal diseases. We used the new international definitions of influenza-associated pulmonary aspergillosis (IAPA) and COVID-19-associated pulmonary aspergillosis (CAPA) to compare the demographic, clinical, biological, and radiological aspects of IAPA and CAPA in a monocentric retrospective study. A total of 120 patients were included, 71 with influenza and 49 with COVID-19-associated ARDS. Among them, 27 fulfilled the newly published criteria of IPA: 17/71 IAPA (23.9%) and 10/49 CAPA (20.4%). Kaplan–Meier curves showed significantly higher 90-day mortality for IPA patients overall (p = 0.032), whereas mortality did not differ between CAPA and IAPA patients. Radiological findings showed differences between IAPA and CAPA, with a higher proportion of features suggestive of IPA during IAPA. Lastly, a wide proportion of IPA patients had low plasma voriconazole concentrations with a higher delay to reach concentrations > 2 mg/L in CAPA vs. IAPA patients (p = 0.045). Severe COVID-19 and influenza patients appeared very similar in terms of prevalence of IPA and outcome. The dramatic consequences on the patients’ prognosis emphasize the need for a better awareness in these particular populations.
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spelling pubmed-81563732021-05-28 Influenza- and COVID-19-Associated Pulmonary Aspergillosis: Are the Pictures Different? Reizine, Florian Pinceaux, Kieran Lederlin, Mathieu Autier, Brice Guegan, Hélène Gacouin, Arnaud Luque-Paz, David Boglione-Kerrien, Christelle Bacle, Astrid Le Daré, Brendan Launey, Yoann Lesouhaitier, Mathieu Painvin, Benoit Camus, Christophe Mansour, Alexandre Robert-Gangneux, Florence Belaz, Sorya Le Tulzo, Yves Tadié, Jean-Marc Maamar, Adel Gangneux, Jean-Pierre J Fungi (Basel) Article Invasive pulmonary aspergillosis (IPA) in intensive care unit patients is a major concern. Influenza-associated acute respiratory distress syndrome (ARDS) and severe COVID-19 patients are both at risk of developing invasive fungal diseases. We used the new international definitions of influenza-associated pulmonary aspergillosis (IAPA) and COVID-19-associated pulmonary aspergillosis (CAPA) to compare the demographic, clinical, biological, and radiological aspects of IAPA and CAPA in a monocentric retrospective study. A total of 120 patients were included, 71 with influenza and 49 with COVID-19-associated ARDS. Among them, 27 fulfilled the newly published criteria of IPA: 17/71 IAPA (23.9%) and 10/49 CAPA (20.4%). Kaplan–Meier curves showed significantly higher 90-day mortality for IPA patients overall (p = 0.032), whereas mortality did not differ between CAPA and IAPA patients. Radiological findings showed differences between IAPA and CAPA, with a higher proportion of features suggestive of IPA during IAPA. Lastly, a wide proportion of IPA patients had low plasma voriconazole concentrations with a higher delay to reach concentrations > 2 mg/L in CAPA vs. IAPA patients (p = 0.045). Severe COVID-19 and influenza patients appeared very similar in terms of prevalence of IPA and outcome. The dramatic consequences on the patients’ prognosis emphasize the need for a better awareness in these particular populations. MDPI 2021-05-15 /pmc/articles/PMC8156373/ /pubmed/34063556 http://dx.doi.org/10.3390/jof7050388 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Reizine, Florian
Pinceaux, Kieran
Lederlin, Mathieu
Autier, Brice
Guegan, Hélène
Gacouin, Arnaud
Luque-Paz, David
Boglione-Kerrien, Christelle
Bacle, Astrid
Le Daré, Brendan
Launey, Yoann
Lesouhaitier, Mathieu
Painvin, Benoit
Camus, Christophe
Mansour, Alexandre
Robert-Gangneux, Florence
Belaz, Sorya
Le Tulzo, Yves
Tadié, Jean-Marc
Maamar, Adel
Gangneux, Jean-Pierre
Influenza- and COVID-19-Associated Pulmonary Aspergillosis: Are the Pictures Different?
title Influenza- and COVID-19-Associated Pulmonary Aspergillosis: Are the Pictures Different?
title_full Influenza- and COVID-19-Associated Pulmonary Aspergillosis: Are the Pictures Different?
title_fullStr Influenza- and COVID-19-Associated Pulmonary Aspergillosis: Are the Pictures Different?
title_full_unstemmed Influenza- and COVID-19-Associated Pulmonary Aspergillosis: Are the Pictures Different?
title_short Influenza- and COVID-19-Associated Pulmonary Aspergillosis: Are the Pictures Different?
title_sort influenza- and covid-19-associated pulmonary aspergillosis: are the pictures different?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156373/
https://www.ncbi.nlm.nih.gov/pubmed/34063556
http://dx.doi.org/10.3390/jof7050388
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