Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment

Exosomes are nanoscale vesicles generated by cells for intercellular communication. Due to their composition, significant research has been conducted to transform these particles into specific delivery systems for various disease states. In this review, we discuss the common isolation and loading me...

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Autores principales: Massey, Andrew E., Malik, Shabnam, Sikander, Mohammad, Doxtater, Kyle A., Tripathi, Manish K., Khan, Sheema, Yallapu, Murali M., Jaggi, Meena, Chauhan, Subhash C., Hafeez, Bilal B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156384/
https://www.ncbi.nlm.nih.gov/pubmed/34067896
http://dx.doi.org/10.3390/ijms22105278
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author Massey, Andrew E.
Malik, Shabnam
Sikander, Mohammad
Doxtater, Kyle A.
Tripathi, Manish K.
Khan, Sheema
Yallapu, Murali M.
Jaggi, Meena
Chauhan, Subhash C.
Hafeez, Bilal B.
author_facet Massey, Andrew E.
Malik, Shabnam
Sikander, Mohammad
Doxtater, Kyle A.
Tripathi, Manish K.
Khan, Sheema
Yallapu, Murali M.
Jaggi, Meena
Chauhan, Subhash C.
Hafeez, Bilal B.
author_sort Massey, Andrew E.
collection PubMed
description Exosomes are nanoscale vesicles generated by cells for intercellular communication. Due to their composition, significant research has been conducted to transform these particles into specific delivery systems for various disease states. In this review, we discuss the common isolation and loading methods of exosomes, some of the major roles of exosomes in the tumor microenvironment, as well as discuss recent applications of exosomes as drug delivery vessels and the resulting clinical implications.
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spelling pubmed-81563842021-05-28 Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment Massey, Andrew E. Malik, Shabnam Sikander, Mohammad Doxtater, Kyle A. Tripathi, Manish K. Khan, Sheema Yallapu, Murali M. Jaggi, Meena Chauhan, Subhash C. Hafeez, Bilal B. Int J Mol Sci Review Exosomes are nanoscale vesicles generated by cells for intercellular communication. Due to their composition, significant research has been conducted to transform these particles into specific delivery systems for various disease states. In this review, we discuss the common isolation and loading methods of exosomes, some of the major roles of exosomes in the tumor microenvironment, as well as discuss recent applications of exosomes as drug delivery vessels and the resulting clinical implications. MDPI 2021-05-17 /pmc/articles/PMC8156384/ /pubmed/34067896 http://dx.doi.org/10.3390/ijms22105278 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Massey, Andrew E.
Malik, Shabnam
Sikander, Mohammad
Doxtater, Kyle A.
Tripathi, Manish K.
Khan, Sheema
Yallapu, Murali M.
Jaggi, Meena
Chauhan, Subhash C.
Hafeez, Bilal B.
Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment
title Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment
title_full Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment
title_fullStr Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment
title_full_unstemmed Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment
title_short Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment
title_sort clinical implications of exosomes: targeted drug delivery for cancer treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156384/
https://www.ncbi.nlm.nih.gov/pubmed/34067896
http://dx.doi.org/10.3390/ijms22105278
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