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Endometriosis and Cancer: Exploring the Role of Macrophages
Endometriosis and cancer have much in common, notably their burgeoning of cells in hypoxic milieus, their invasiveness, and their capacity to trigger remodeling, vascularization, and innervation of other tissues. An important role in these processes is played by permissive microenvironments inhabite...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156385/ https://www.ncbi.nlm.nih.gov/pubmed/34068967 http://dx.doi.org/10.3390/ijms22105196 |
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author | Artemova, Daria Vishnyakova, Polina Khashchenko, Elena Elchaninov, Andrey Sukhikh, Gennady Fatkhudinov, Timur |
author_facet | Artemova, Daria Vishnyakova, Polina Khashchenko, Elena Elchaninov, Andrey Sukhikh, Gennady Fatkhudinov, Timur |
author_sort | Artemova, Daria |
collection | PubMed |
description | Endometriosis and cancer have much in common, notably their burgeoning of cells in hypoxic milieus, their invasiveness, and their capacity to trigger remodeling, vascularization, and innervation of other tissues. An important role in these processes is played by permissive microenvironments inhabited by a variety of stromal and immune cells, including macrophages. Remarkable phenotypical plasticity of macrophages makes them a promising therapeutic target; some key issues are the range of macrophage phenotypes characteristic of a particular pathology and the possible manners of its modulation. In both endometriosis and cancer, macrophages guard the lesions from immune surveillance while promoting pathological cell growth, invasion, and metastasis. This review article focuses on a comparative analysis of macrophage behaviors in endometriosis and cancer. We also highlight recent reports on the experimental modulation of macrophage phenotypes in preclinical models of endometriosis and cancer. |
format | Online Article Text |
id | pubmed-8156385 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81563852021-05-28 Endometriosis and Cancer: Exploring the Role of Macrophages Artemova, Daria Vishnyakova, Polina Khashchenko, Elena Elchaninov, Andrey Sukhikh, Gennady Fatkhudinov, Timur Int J Mol Sci Review Endometriosis and cancer have much in common, notably their burgeoning of cells in hypoxic milieus, their invasiveness, and their capacity to trigger remodeling, vascularization, and innervation of other tissues. An important role in these processes is played by permissive microenvironments inhabited by a variety of stromal and immune cells, including macrophages. Remarkable phenotypical plasticity of macrophages makes them a promising therapeutic target; some key issues are the range of macrophage phenotypes characteristic of a particular pathology and the possible manners of its modulation. In both endometriosis and cancer, macrophages guard the lesions from immune surveillance while promoting pathological cell growth, invasion, and metastasis. This review article focuses on a comparative analysis of macrophage behaviors in endometriosis and cancer. We also highlight recent reports on the experimental modulation of macrophage phenotypes in preclinical models of endometriosis and cancer. MDPI 2021-05-14 /pmc/articles/PMC8156385/ /pubmed/34068967 http://dx.doi.org/10.3390/ijms22105196 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Artemova, Daria Vishnyakova, Polina Khashchenko, Elena Elchaninov, Andrey Sukhikh, Gennady Fatkhudinov, Timur Endometriosis and Cancer: Exploring the Role of Macrophages |
title | Endometriosis and Cancer: Exploring the Role of Macrophages |
title_full | Endometriosis and Cancer: Exploring the Role of Macrophages |
title_fullStr | Endometriosis and Cancer: Exploring the Role of Macrophages |
title_full_unstemmed | Endometriosis and Cancer: Exploring the Role of Macrophages |
title_short | Endometriosis and Cancer: Exploring the Role of Macrophages |
title_sort | endometriosis and cancer: exploring the role of macrophages |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156385/ https://www.ncbi.nlm.nih.gov/pubmed/34068967 http://dx.doi.org/10.3390/ijms22105196 |
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