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The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes
In order to improve pharmaceutical properties of drugs, complexes are synthesized as combinations with other chemical substances. The complexes of fenamic acid and its derivatives, such as mefenamic-, tolfenamic- and flufenamic acid, with acridine were obtained and the X-ray structures were discusse...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156396/ https://www.ncbi.nlm.nih.gov/pubmed/34065674 http://dx.doi.org/10.3390/molecules26102956 |
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author | Krawczyk, Marta S. Sroka, Adam Majerz, Irena |
author_facet | Krawczyk, Marta S. Sroka, Adam Majerz, Irena |
author_sort | Krawczyk, Marta S. |
collection | PubMed |
description | In order to improve pharmaceutical properties of drugs, complexes are synthesized as combinations with other chemical substances. The complexes of fenamic acid and its derivatives, such as mefenamic-, tolfenamic- and flufenamic acid, with acridine were obtained and the X-ray structures were discussed. Formation of the crystals is determined by the presence of the intermolecular O–H(…)N hydrogen bond that occur between fenamic acids and acridine. Intermolecular interactions stabilizing the crystals such as π(…)π stacking, C–H(…)X (X = O, Cl) intermolecular hydrogen bonds as well as C–H(…)π and other dispersive interactions were analyzed by theoretical methods: the quantum theory of atoms in molecules (QTAIM) and noncovalent interaction (NCI) approaches. |
format | Online Article Text |
id | pubmed-8156396 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81563962021-05-28 The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes Krawczyk, Marta S. Sroka, Adam Majerz, Irena Molecules Article In order to improve pharmaceutical properties of drugs, complexes are synthesized as combinations with other chemical substances. The complexes of fenamic acid and its derivatives, such as mefenamic-, tolfenamic- and flufenamic acid, with acridine were obtained and the X-ray structures were discussed. Formation of the crystals is determined by the presence of the intermolecular O–H(…)N hydrogen bond that occur between fenamic acids and acridine. Intermolecular interactions stabilizing the crystals such as π(…)π stacking, C–H(…)X (X = O, Cl) intermolecular hydrogen bonds as well as C–H(…)π and other dispersive interactions were analyzed by theoretical methods: the quantum theory of atoms in molecules (QTAIM) and noncovalent interaction (NCI) approaches. MDPI 2021-05-16 /pmc/articles/PMC8156396/ /pubmed/34065674 http://dx.doi.org/10.3390/molecules26102956 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Krawczyk, Marta S. Sroka, Adam Majerz, Irena The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes |
title | The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes |
title_full | The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes |
title_fullStr | The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes |
title_full_unstemmed | The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes |
title_short | The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes |
title_sort | crystal structure and intermolecular interactions in fenamic acids–acridine complexes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156396/ https://www.ncbi.nlm.nih.gov/pubmed/34065674 http://dx.doi.org/10.3390/molecules26102956 |
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