Role of Steroid Hormones in the Pathogenesis of Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and may progress to cirrhosis or even hepatocellular carcinoma. A number of steroid hormones are important regulators of lipid homeostasis through fine tuning the expression of genes related to lipid synthesis...

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Detalles Bibliográficos
Autores principales: Yang, Meng, Ma, Feng, Guan, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156407/
https://www.ncbi.nlm.nih.gov/pubmed/34067649
http://dx.doi.org/10.3390/metabo11050320
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author Yang, Meng
Ma, Feng
Guan, Min
author_facet Yang, Meng
Ma, Feng
Guan, Min
author_sort Yang, Meng
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and may progress to cirrhosis or even hepatocellular carcinoma. A number of steroid hormones are important regulators of lipid homeostasis through fine tuning the expression of genes related to lipid synthesis, export, and metabolism. Dysregulation of such pathways has been implicated in the pathogenesis of NAFLD. The aim of this review is to clarify the potential impact of steroid hormones on NAFLD. We also highlight potential interventions through modulating steroid hormone levels or the activities of their cognate receptors as therapeutic strategies for preventing NAFLD.
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spelling pubmed-81564072021-05-28 Role of Steroid Hormones in the Pathogenesis of Nonalcoholic Fatty Liver Disease Yang, Meng Ma, Feng Guan, Min Metabolites Review Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and may progress to cirrhosis or even hepatocellular carcinoma. A number of steroid hormones are important regulators of lipid homeostasis through fine tuning the expression of genes related to lipid synthesis, export, and metabolism. Dysregulation of such pathways has been implicated in the pathogenesis of NAFLD. The aim of this review is to clarify the potential impact of steroid hormones on NAFLD. We also highlight potential interventions through modulating steroid hormone levels or the activities of their cognate receptors as therapeutic strategies for preventing NAFLD. MDPI 2021-05-17 /pmc/articles/PMC8156407/ /pubmed/34067649 http://dx.doi.org/10.3390/metabo11050320 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yang, Meng
Ma, Feng
Guan, Min
Role of Steroid Hormones in the Pathogenesis of Nonalcoholic Fatty Liver Disease
title Role of Steroid Hormones in the Pathogenesis of Nonalcoholic Fatty Liver Disease
title_full Role of Steroid Hormones in the Pathogenesis of Nonalcoholic Fatty Liver Disease
title_fullStr Role of Steroid Hormones in the Pathogenesis of Nonalcoholic Fatty Liver Disease
title_full_unstemmed Role of Steroid Hormones in the Pathogenesis of Nonalcoholic Fatty Liver Disease
title_short Role of Steroid Hormones in the Pathogenesis of Nonalcoholic Fatty Liver Disease
title_sort role of steroid hormones in the pathogenesis of nonalcoholic fatty liver disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156407/
https://www.ncbi.nlm.nih.gov/pubmed/34067649
http://dx.doi.org/10.3390/metabo11050320
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