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Angiotensinergic Neurotransmissions in the Medial Amygdala Nucleus Modulate Behavioral Changes in the Forced Swimming Test Evoked by Acute Restraint Stress in Rats

We investigated the role of angiotensin II type 1 (AT(1) receptor) and type 2 (AT(2) receptor) and MAS receptors present in the medial amygdaloid nucleus (MeA) in behavioral changes in the forced swimming test (FST) evoked by acute restraint stress in male rats. For this, rats received bilateral mic...

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Autores principales: Marchi-Coelho, Camila, Costa-Ferreira, Willian, Reis-Silva, Lilian L., Crestani, Carlos C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156471/
https://www.ncbi.nlm.nih.gov/pubmed/34067508
http://dx.doi.org/10.3390/cells10051217
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author Marchi-Coelho, Camila
Costa-Ferreira, Willian
Reis-Silva, Lilian L.
Crestani, Carlos C.
author_facet Marchi-Coelho, Camila
Costa-Ferreira, Willian
Reis-Silva, Lilian L.
Crestani, Carlos C.
author_sort Marchi-Coelho, Camila
collection PubMed
description We investigated the role of angiotensin II type 1 (AT(1) receptor) and type 2 (AT(2) receptor) and MAS receptors present in the medial amygdaloid nucleus (MeA) in behavioral changes in the forced swimming test (FST) evoked by acute restraint stress in male rats. For this, rats received bilateral microinjection of either the selective AT(1) receptor antagonist losartan, the selective AT(2) receptor antagonist PD123319, the selective MAS receptor antagonist A-779, or vehicle 10 min before a 60 min restraint session. Then, behavior in the FST was evaluated immediately after the restraint (15 min session) and 24 h later (5 min session). The behavior in the FST of a non-stressed group was also evaluated. We observed that acute restraint stress decreased immobility during both sessions of the FST in animals treated with vehicle in the MeA. The decreased immobility during the first session was inhibited by intra-MeA administration of PD123319, whereas the effect during the second session was not identified in animals treated with A-779 into the MeA. Microinjection of PD123319 into the MeA also affected the pattern of active behaviors (i.e., swimming and climbing) during the second session of the FST. Taken together, these results indicate an involvement of angiotensinergic neurotransmissions within the MeA in behavioral changes in the FST evoked by stress.
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spelling pubmed-81564712021-05-28 Angiotensinergic Neurotransmissions in the Medial Amygdala Nucleus Modulate Behavioral Changes in the Forced Swimming Test Evoked by Acute Restraint Stress in Rats Marchi-Coelho, Camila Costa-Ferreira, Willian Reis-Silva, Lilian L. Crestani, Carlos C. Cells Article We investigated the role of angiotensin II type 1 (AT(1) receptor) and type 2 (AT(2) receptor) and MAS receptors present in the medial amygdaloid nucleus (MeA) in behavioral changes in the forced swimming test (FST) evoked by acute restraint stress in male rats. For this, rats received bilateral microinjection of either the selective AT(1) receptor antagonist losartan, the selective AT(2) receptor antagonist PD123319, the selective MAS receptor antagonist A-779, or vehicle 10 min before a 60 min restraint session. Then, behavior in the FST was evaluated immediately after the restraint (15 min session) and 24 h later (5 min session). The behavior in the FST of a non-stressed group was also evaluated. We observed that acute restraint stress decreased immobility during both sessions of the FST in animals treated with vehicle in the MeA. The decreased immobility during the first session was inhibited by intra-MeA administration of PD123319, whereas the effect during the second session was not identified in animals treated with A-779 into the MeA. Microinjection of PD123319 into the MeA also affected the pattern of active behaviors (i.e., swimming and climbing) during the second session of the FST. Taken together, these results indicate an involvement of angiotensinergic neurotransmissions within the MeA in behavioral changes in the FST evoked by stress. MDPI 2021-05-17 /pmc/articles/PMC8156471/ /pubmed/34067508 http://dx.doi.org/10.3390/cells10051217 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Marchi-Coelho, Camila
Costa-Ferreira, Willian
Reis-Silva, Lilian L.
Crestani, Carlos C.
Angiotensinergic Neurotransmissions in the Medial Amygdala Nucleus Modulate Behavioral Changes in the Forced Swimming Test Evoked by Acute Restraint Stress in Rats
title Angiotensinergic Neurotransmissions in the Medial Amygdala Nucleus Modulate Behavioral Changes in the Forced Swimming Test Evoked by Acute Restraint Stress in Rats
title_full Angiotensinergic Neurotransmissions in the Medial Amygdala Nucleus Modulate Behavioral Changes in the Forced Swimming Test Evoked by Acute Restraint Stress in Rats
title_fullStr Angiotensinergic Neurotransmissions in the Medial Amygdala Nucleus Modulate Behavioral Changes in the Forced Swimming Test Evoked by Acute Restraint Stress in Rats
title_full_unstemmed Angiotensinergic Neurotransmissions in the Medial Amygdala Nucleus Modulate Behavioral Changes in the Forced Swimming Test Evoked by Acute Restraint Stress in Rats
title_short Angiotensinergic Neurotransmissions in the Medial Amygdala Nucleus Modulate Behavioral Changes in the Forced Swimming Test Evoked by Acute Restraint Stress in Rats
title_sort angiotensinergic neurotransmissions in the medial amygdala nucleus modulate behavioral changes in the forced swimming test evoked by acute restraint stress in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156471/
https://www.ncbi.nlm.nih.gov/pubmed/34067508
http://dx.doi.org/10.3390/cells10051217
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