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Ileo-Colon Targeting of the Poorly Water-Soluble Drug Celecoxib Using a pH-Dependent Coating in Combination with Self-Emulsifying Drug Delivery or Solid Dispersion Systems

Targeting celecoxib to the ileo-colonic region could be beneficial for the treatment and prevention of colon cancer. Ileo-colonic targeting can be achieved by using pH-dependent coating systems such as ColoPulse. Celecoxib has poor aqueous solubility, which may jeopardize optimal treatment. Therefor...

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Detalles Bibliográficos
Autores principales:	Broesder, Annemarie, Berends, Julia M. E., Scheepers, Sophie M., Nguyen, Duong N., Frijlink, Henderik W., Hinrichs, Wouter L. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156508/ https://www.ncbi.nlm.nih.gov/pubmed/34063521 http://dx.doi.org/10.3390/pharmaceutics13050731

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