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Effects of Soy Isoflavones on Biochemical Markers of Bone Metabolism in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

This systematic review and meta-analysis of randomized controlled trials was performed to more completely assess potential changes in bone turnover marker levels in postmenopausal women during the intake of soy isoflavones. PubMed (Medline) and EMBASE were searched for relevant studies, and their qu...

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Autores principales: Kanadys, Wiesław, Barańska, Agnieszka, Błaszczuk, Agata, Polz-Dacewicz, Małgorzata, Drop, Bartłomiej, Malm, Maria, Kanecki, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156509/
https://www.ncbi.nlm.nih.gov/pubmed/34067865
http://dx.doi.org/10.3390/ijerph18105346
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author Kanadys, Wiesław
Barańska, Agnieszka
Błaszczuk, Agata
Polz-Dacewicz, Małgorzata
Drop, Bartłomiej
Malm, Maria
Kanecki, Krzysztof
author_facet Kanadys, Wiesław
Barańska, Agnieszka
Błaszczuk, Agata
Polz-Dacewicz, Małgorzata
Drop, Bartłomiej
Malm, Maria
Kanecki, Krzysztof
author_sort Kanadys, Wiesław
collection PubMed
description This systematic review and meta-analysis of randomized controlled trials was performed to more completely assess potential changes in bone turnover marker levels in postmenopausal women during the intake of soy isoflavones. PubMed (Medline) and EMBASE were searched for relevant studies, and their quality was evaluated according to Cochrane criteria. The levels of markers were evaluated in a total of 1114 women who ingested mean daily doses of 98.2 mg (30.9 to 300) of soy isoflavones for 3 to 24 months, in comparison to those of 1081 subjects who used a placebo. Ten, eighteen, eight, and fourteen comparison studies were finally selected for an estimation of the effects on osteocalcin (OC), bone alkaline phosphatase (BAP), pyridinoline (PYD), and deoxypyridinoline (DPD), respectively. A summary of the results of intervention was as follows: 4.16%, 95% CI: −7.72–16.04, p = 0.49 for OC; 5.50%, 95% CI: −3.81–14.82, p = 0.25 for BAP; −12.09%, 95% CI: −25.37–1.20, p = 0.07 for PYD; and −7.48%, 95% CI: −15.37–0.41, p = 0.06 for DPD. The meta-analysis of the included studies revealed some statistically insignificant observations that soy isoflavones intake is associated with a trend in increased levels of OC and BAP, as well as a trend in reduced levels of PYD and DPD. Soy isoflavones may have a beneficial effect on bone formation markers, but this requires extensive multi-center research.
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spelling pubmed-81565092021-05-28 Effects of Soy Isoflavones on Biochemical Markers of Bone Metabolism in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Kanadys, Wiesław Barańska, Agnieszka Błaszczuk, Agata Polz-Dacewicz, Małgorzata Drop, Bartłomiej Malm, Maria Kanecki, Krzysztof Int J Environ Res Public Health Review This systematic review and meta-analysis of randomized controlled trials was performed to more completely assess potential changes in bone turnover marker levels in postmenopausal women during the intake of soy isoflavones. PubMed (Medline) and EMBASE were searched for relevant studies, and their quality was evaluated according to Cochrane criteria. The levels of markers were evaluated in a total of 1114 women who ingested mean daily doses of 98.2 mg (30.9 to 300) of soy isoflavones for 3 to 24 months, in comparison to those of 1081 subjects who used a placebo. Ten, eighteen, eight, and fourteen comparison studies were finally selected for an estimation of the effects on osteocalcin (OC), bone alkaline phosphatase (BAP), pyridinoline (PYD), and deoxypyridinoline (DPD), respectively. A summary of the results of intervention was as follows: 4.16%, 95% CI: −7.72–16.04, p = 0.49 for OC; 5.50%, 95% CI: −3.81–14.82, p = 0.25 for BAP; −12.09%, 95% CI: −25.37–1.20, p = 0.07 for PYD; and −7.48%, 95% CI: −15.37–0.41, p = 0.06 for DPD. The meta-analysis of the included studies revealed some statistically insignificant observations that soy isoflavones intake is associated with a trend in increased levels of OC and BAP, as well as a trend in reduced levels of PYD and DPD. Soy isoflavones may have a beneficial effect on bone formation markers, but this requires extensive multi-center research. MDPI 2021-05-17 /pmc/articles/PMC8156509/ /pubmed/34067865 http://dx.doi.org/10.3390/ijerph18105346 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kanadys, Wiesław
Barańska, Agnieszka
Błaszczuk, Agata
Polz-Dacewicz, Małgorzata
Drop, Bartłomiej
Malm, Maria
Kanecki, Krzysztof
Effects of Soy Isoflavones on Biochemical Markers of Bone Metabolism in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title Effects of Soy Isoflavones on Biochemical Markers of Bone Metabolism in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_full Effects of Soy Isoflavones on Biochemical Markers of Bone Metabolism in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_fullStr Effects of Soy Isoflavones on Biochemical Markers of Bone Metabolism in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_full_unstemmed Effects of Soy Isoflavones on Biochemical Markers of Bone Metabolism in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_short Effects of Soy Isoflavones on Biochemical Markers of Bone Metabolism in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_sort effects of soy isoflavones on biochemical markers of bone metabolism in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156509/
https://www.ncbi.nlm.nih.gov/pubmed/34067865
http://dx.doi.org/10.3390/ijerph18105346
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