A Concise Synthesis of a BODIPY-Labeled Tetrasaccharide Related to the Antitumor PI-88

A convergent synthetic route to a tetrasaccharide related to PI-88, which allows the incorporation of a fluorescent BODIPY-label at the reducing-end, has been developed. The strategy, which features the use of 1,2-methyl orthoesters (MeOEs) as glycosyl donors, illustrates the usefulness of suitably-...

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Autores principales: Ventura, Juan, Uriel, Clara, Gomez, Ana M., Avellanal-Zaballa, Edurne, Bañuelos, Jorge, García-Moreno, Inmaculada, Lopez, Jose Cristobal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156587/
https://www.ncbi.nlm.nih.gov/pubmed/34068920
http://dx.doi.org/10.3390/molecules26102909
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author Ventura, Juan
Uriel, Clara
Gomez, Ana M.
Avellanal-Zaballa, Edurne
Bañuelos, Jorge
García-Moreno, Inmaculada
Lopez, Jose Cristobal
author_facet Ventura, Juan
Uriel, Clara
Gomez, Ana M.
Avellanal-Zaballa, Edurne
Bañuelos, Jorge
García-Moreno, Inmaculada
Lopez, Jose Cristobal
author_sort Ventura, Juan
collection PubMed
description A convergent synthetic route to a tetrasaccharide related to PI-88, which allows the incorporation of a fluorescent BODIPY-label at the reducing-end, has been developed. The strategy, which features the use of 1,2-methyl orthoesters (MeOEs) as glycosyl donors, illustrates the usefulness of suitably-designed BODIPY dyes as glycosyl labels in synthetic strategies towards fluorescently-tagged oligosaccharides.
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spelling pubmed-81565872021-05-28 A Concise Synthesis of a BODIPY-Labeled Tetrasaccharide Related to the Antitumor PI-88 Ventura, Juan Uriel, Clara Gomez, Ana M. Avellanal-Zaballa, Edurne Bañuelos, Jorge García-Moreno, Inmaculada Lopez, Jose Cristobal Molecules Article A convergent synthetic route to a tetrasaccharide related to PI-88, which allows the incorporation of a fluorescent BODIPY-label at the reducing-end, has been developed. The strategy, which features the use of 1,2-methyl orthoesters (MeOEs) as glycosyl donors, illustrates the usefulness of suitably-designed BODIPY dyes as glycosyl labels in synthetic strategies towards fluorescently-tagged oligosaccharides. MDPI 2021-05-14 /pmc/articles/PMC8156587/ /pubmed/34068920 http://dx.doi.org/10.3390/molecules26102909 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ventura, Juan
Uriel, Clara
Gomez, Ana M.
Avellanal-Zaballa, Edurne
Bañuelos, Jorge
García-Moreno, Inmaculada
Lopez, Jose Cristobal
A Concise Synthesis of a BODIPY-Labeled Tetrasaccharide Related to the Antitumor PI-88
title A Concise Synthesis of a BODIPY-Labeled Tetrasaccharide Related to the Antitumor PI-88
title_full A Concise Synthesis of a BODIPY-Labeled Tetrasaccharide Related to the Antitumor PI-88
title_fullStr A Concise Synthesis of a BODIPY-Labeled Tetrasaccharide Related to the Antitumor PI-88
title_full_unstemmed A Concise Synthesis of a BODIPY-Labeled Tetrasaccharide Related to the Antitumor PI-88
title_short A Concise Synthesis of a BODIPY-Labeled Tetrasaccharide Related to the Antitumor PI-88
title_sort concise synthesis of a bodipy-labeled tetrasaccharide related to the antitumor pi-88
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156587/
https://www.ncbi.nlm.nih.gov/pubmed/34068920
http://dx.doi.org/10.3390/molecules26102909
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