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Prognostic Impact of Pretreatment 2-[(18)F]-FDG PET/CT Parameters in Primary Gastric DLBCL

Background and Objectives: Primary gastric diffuse large-B cell lymphoma (DLBCL) is an aggressive lymphoma subtype with high (18)F-FDG avidity but unclear criteria for 2-[(18)F]-FDG PET/CT in the evaluation of treatment response and prognostication. Our aim was to investigate whether the pretreatmen...

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Autores principales: Albano, Domenico, Dondi, Francesco, Mazzoletti, Angelica, Bellini, Pietro, Giubbini, Raffaele, Bertagna, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156603/
https://www.ncbi.nlm.nih.gov/pubmed/34069203
http://dx.doi.org/10.3390/medicina57050498
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author Albano, Domenico
Dondi, Francesco
Mazzoletti, Angelica
Bellini, Pietro
Giubbini, Raffaele
Bertagna, Francesco
author_facet Albano, Domenico
Dondi, Francesco
Mazzoletti, Angelica
Bellini, Pietro
Giubbini, Raffaele
Bertagna, Francesco
author_sort Albano, Domenico
collection PubMed
description Background and Objectives: Primary gastric diffuse large-B cell lymphoma (DLBCL) is an aggressive lymphoma subtype with high (18)F-FDG avidity but unclear criteria for 2-[(18)F]-FDG PET/CT in the evaluation of treatment response and prognostication. Our aim was to investigate whether the pretreatment 2-[(18)F]-FDG PET/CT variables may predict treatment response (at end of first-line therapy) and prognosis in primary gastric DLBCL. Materials and Methods: we included 57 patients with a diagnosis of primary gastric DLBCL and a baseline 2-[(18)F]-FDG PET/CT and an end of treatment PET/CT after 6 cycles of R-CHOP chemotherapy. We analyzed PET images qualitatively and semi-quantitatively by deriving the maximum standardized uptake value body weight (SUVbw), the maximum standardized uptake value lean body mass (SUVlbm), the maximum standardized uptake value body surface area (SUVbsa), lesion to liver SUVmax ratio (L-L SUV R), lesion to blood-pool SUVmax ratio (L-BP SUV R), metabolic tumor volume and total lesion glycolysis of gastric lesion (gMTV and gTLG), and total MTV (tMTV) and TLG. Survival curves were plotted according to the Kaplan–Meier analysis. Results: at a median follow up of 80 months, the median PFS and OS were 69 and 80 months. Baseline gMTV, gTLG, tMTV, and TLG were significantly higher in patients with incomplete response (partial response and progression) compared to complete response group. tMTV and TLG were confirmed to be independent prognostic factors both for PFS (p = 0.023 and p = 0.038) and OS (p = 0.038 and p = 0.026); instead, the other metabolic parameters were not related to outcome survival. Conclusions: high tMTV and TLG were significantly correlated with shorter survival (PFS and OS) and may predict incomplete response after therapy.
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spelling pubmed-81566032021-05-28 Prognostic Impact of Pretreatment 2-[(18)F]-FDG PET/CT Parameters in Primary Gastric DLBCL Albano, Domenico Dondi, Francesco Mazzoletti, Angelica Bellini, Pietro Giubbini, Raffaele Bertagna, Francesco Medicina (Kaunas) Article Background and Objectives: Primary gastric diffuse large-B cell lymphoma (DLBCL) is an aggressive lymphoma subtype with high (18)F-FDG avidity but unclear criteria for 2-[(18)F]-FDG PET/CT in the evaluation of treatment response and prognostication. Our aim was to investigate whether the pretreatment 2-[(18)F]-FDG PET/CT variables may predict treatment response (at end of first-line therapy) and prognosis in primary gastric DLBCL. Materials and Methods: we included 57 patients with a diagnosis of primary gastric DLBCL and a baseline 2-[(18)F]-FDG PET/CT and an end of treatment PET/CT after 6 cycles of R-CHOP chemotherapy. We analyzed PET images qualitatively and semi-quantitatively by deriving the maximum standardized uptake value body weight (SUVbw), the maximum standardized uptake value lean body mass (SUVlbm), the maximum standardized uptake value body surface area (SUVbsa), lesion to liver SUVmax ratio (L-L SUV R), lesion to blood-pool SUVmax ratio (L-BP SUV R), metabolic tumor volume and total lesion glycolysis of gastric lesion (gMTV and gTLG), and total MTV (tMTV) and TLG. Survival curves were plotted according to the Kaplan–Meier analysis. Results: at a median follow up of 80 months, the median PFS and OS were 69 and 80 months. Baseline gMTV, gTLG, tMTV, and TLG were significantly higher in patients with incomplete response (partial response and progression) compared to complete response group. tMTV and TLG were confirmed to be independent prognostic factors both for PFS (p = 0.023 and p = 0.038) and OS (p = 0.038 and p = 0.026); instead, the other metabolic parameters were not related to outcome survival. Conclusions: high tMTV and TLG were significantly correlated with shorter survival (PFS and OS) and may predict incomplete response after therapy. MDPI 2021-05-14 /pmc/articles/PMC8156603/ /pubmed/34069203 http://dx.doi.org/10.3390/medicina57050498 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Albano, Domenico
Dondi, Francesco
Mazzoletti, Angelica
Bellini, Pietro
Giubbini, Raffaele
Bertagna, Francesco
Prognostic Impact of Pretreatment 2-[(18)F]-FDG PET/CT Parameters in Primary Gastric DLBCL
title Prognostic Impact of Pretreatment 2-[(18)F]-FDG PET/CT Parameters in Primary Gastric DLBCL
title_full Prognostic Impact of Pretreatment 2-[(18)F]-FDG PET/CT Parameters in Primary Gastric DLBCL
title_fullStr Prognostic Impact of Pretreatment 2-[(18)F]-FDG PET/CT Parameters in Primary Gastric DLBCL
title_full_unstemmed Prognostic Impact of Pretreatment 2-[(18)F]-FDG PET/CT Parameters in Primary Gastric DLBCL
title_short Prognostic Impact of Pretreatment 2-[(18)F]-FDG PET/CT Parameters in Primary Gastric DLBCL
title_sort prognostic impact of pretreatment 2-[(18)f]-fdg pet/ct parameters in primary gastric dlbcl
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156603/
https://www.ncbi.nlm.nih.gov/pubmed/34069203
http://dx.doi.org/10.3390/medicina57050498
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