Development of Phosphodiesterase–Protein-Kinase Complexes as Novel Targets for Discovery of Inhibitors with Enhanced Specificity

Phosphodiesterases (PDEs) hydrolyze cyclic nucleotides to modulate multiple signaling events in cells. PDEs are recognized to actively associate with cyclic nucleotide receptors (protein kinases, PKs) in larger macromolecular assemblies referred to as signalosomes. Complexation of PDEs with PKs gene...

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Detalles Bibliográficos
Autores principales: Tulsian, Nikhil K., Sin, Valerie Jia-En, Koh, Hwee-Ling, Anand, Ganesh S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156604/
https://www.ncbi.nlm.nih.gov/pubmed/34063491
http://dx.doi.org/10.3390/ijms22105242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156604/
https://www.ncbi.nlm.nih.gov/pubmed/34063491
http://dx.doi.org/10.3390/ijms22105242

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