The Multifunctional Role of EMP3 in the Regulation of Membrane Receptors Associated with IDH-Wild-Type Glioblastoma

Epithelial membrane protein 3 (EMP3) is a tetraspan membrane protein overexpressed in isocitrate dehydrogenase-wild-type (IDH-wt) glioblastoma (GBM). Several studies reported high EMP3 levels as a poor prognostic factor in GBM patients. Experimental findings based on glioma and non-glioma models hav...

Descripción completa

Detalles Bibliográficos
Autores principales: Martija, Antoni Andreu, Pusch, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156612/
https://www.ncbi.nlm.nih.gov/pubmed/34067658
http://dx.doi.org/10.3390/ijms22105261
_version_ 1783699486676090880
author Martija, Antoni Andreu
Pusch, Stefan
author_facet Martija, Antoni Andreu
Pusch, Stefan
author_sort Martija, Antoni Andreu
collection PubMed
description Epithelial membrane protein 3 (EMP3) is a tetraspan membrane protein overexpressed in isocitrate dehydrogenase-wild-type (IDH-wt) glioblastoma (GBM). Several studies reported high EMP3 levels as a poor prognostic factor in GBM patients. Experimental findings based on glioma and non-glioma models have demonstrated the role of EMP3 in the regulation of several membrane proteins known to drive IDH-wt GBM. In this review, we summarize what is currently known about EMP3 biology. We discuss the regulatory effects that EMP3 exerts on a variety of oncogenic receptors and discuss how these mechanisms may relate to IDH-wt GBM. Lastly, we enumerate the open questions towards EMP3 function in IDH-wt GBM.
format Online
Article
Text
id pubmed-8156612
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81566122021-05-28 The Multifunctional Role of EMP3 in the Regulation of Membrane Receptors Associated with IDH-Wild-Type Glioblastoma Martija, Antoni Andreu Pusch, Stefan Int J Mol Sci Review Epithelial membrane protein 3 (EMP3) is a tetraspan membrane protein overexpressed in isocitrate dehydrogenase-wild-type (IDH-wt) glioblastoma (GBM). Several studies reported high EMP3 levels as a poor prognostic factor in GBM patients. Experimental findings based on glioma and non-glioma models have demonstrated the role of EMP3 in the regulation of several membrane proteins known to drive IDH-wt GBM. In this review, we summarize what is currently known about EMP3 biology. We discuss the regulatory effects that EMP3 exerts on a variety of oncogenic receptors and discuss how these mechanisms may relate to IDH-wt GBM. Lastly, we enumerate the open questions towards EMP3 function in IDH-wt GBM. MDPI 2021-05-17 /pmc/articles/PMC8156612/ /pubmed/34067658 http://dx.doi.org/10.3390/ijms22105261 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Martija, Antoni Andreu
Pusch, Stefan
The Multifunctional Role of EMP3 in the Regulation of Membrane Receptors Associated with IDH-Wild-Type Glioblastoma
title The Multifunctional Role of EMP3 in the Regulation of Membrane Receptors Associated with IDH-Wild-Type Glioblastoma
title_full The Multifunctional Role of EMP3 in the Regulation of Membrane Receptors Associated with IDH-Wild-Type Glioblastoma
title_fullStr The Multifunctional Role of EMP3 in the Regulation of Membrane Receptors Associated with IDH-Wild-Type Glioblastoma
title_full_unstemmed The Multifunctional Role of EMP3 in the Regulation of Membrane Receptors Associated with IDH-Wild-Type Glioblastoma
title_short The Multifunctional Role of EMP3 in the Regulation of Membrane Receptors Associated with IDH-Wild-Type Glioblastoma
title_sort multifunctional role of emp3 in the regulation of membrane receptors associated with idh-wild-type glioblastoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156612/
https://www.ncbi.nlm.nih.gov/pubmed/34067658
http://dx.doi.org/10.3390/ijms22105261
work_keys_str_mv AT martijaantoniandreu themultifunctionalroleofemp3intheregulationofmembranereceptorsassociatedwithidhwildtypeglioblastoma
AT puschstefan themultifunctionalroleofemp3intheregulationofmembranereceptorsassociatedwithidhwildtypeglioblastoma
AT martijaantoniandreu multifunctionalroleofemp3intheregulationofmembranereceptorsassociatedwithidhwildtypeglioblastoma
AT puschstefan multifunctionalroleofemp3intheregulationofmembranereceptorsassociatedwithidhwildtypeglioblastoma

Ejemplares similares