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The Addition of Endometrial Injury to Freeze-All Strategy in Women with Repeated Implantation Failures

(1) Background: Recurrent implantation failure (RIF) after IVF remains a challenging topic for fertility specialists and a frustrating reality for patients with infertility. Various approaches have been investigated and applied towards the improvement of clinical outcomes. Through a nonrandomized cl...

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Autores principales: Rigos, Ioannis, Athanasiou, Vasileios, Vlahos, Nikolaos, Papantoniou, Nikolaos, Profer, Dimitrios, Siristatidis, Charalampos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156614/
https://www.ncbi.nlm.nih.gov/pubmed/34067637
http://dx.doi.org/10.3390/jcm10102162
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author Rigos, Ioannis
Athanasiou, Vasileios
Vlahos, Nikolaos
Papantoniou, Nikolaos
Profer, Dimitrios
Siristatidis, Charalampos
author_facet Rigos, Ioannis
Athanasiou, Vasileios
Vlahos, Nikolaos
Papantoniou, Nikolaos
Profer, Dimitrios
Siristatidis, Charalampos
author_sort Rigos, Ioannis
collection PubMed
description (1) Background: Recurrent implantation failure (RIF) after IVF remains a challenging topic for fertility specialists and a frustrating reality for patients with infertility. Various approaches have been investigated and applied towards the improvement of clinical outcomes. Through a nonrandomized clinical trial, we evaluated the effect of the combination of hysteroscopic endometrial injury and the freeze-all technique on pregnancy parameters in a cohort of RIF patients; (2) Methods: The study group comprised of 30 patients with RIF that underwent a hysteroscopic endometrial injury prior to a frozen embryo transfer cycle; another 30 patients with RIF, comprising the control group, underwent a standard frozen cycle with no adjuvant treatment before. Live birth comprised the primary outcome. Logistic and Poisson regression analyses were implemented to reveal potential independent predictors for all outcomes. (3) Results: Live birth rates were similar between groups (8/30 vs. 3/30, p = 0.0876). Biochemical and clinical pregnancy and miscarriages were also independent of the procedure (p = 0.7812, p = 0.3436 and p = 0.1213, respectively). The only confounding factor that contributed to biochemical pregnancy was the number of retrieved oocytes (0.1618 ± 0.0819, p = 0.0481); (4) Conclusions: The addition of endometrial injury to the freeze-all strategy in infertile women with RIF does not significantly improve pregnancy rates, including live birth. A properly conducted RCT with adequate sample size could give a robust answer.
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spelling pubmed-81566142021-05-28 The Addition of Endometrial Injury to Freeze-All Strategy in Women with Repeated Implantation Failures Rigos, Ioannis Athanasiou, Vasileios Vlahos, Nikolaos Papantoniou, Nikolaos Profer, Dimitrios Siristatidis, Charalampos J Clin Med Article (1) Background: Recurrent implantation failure (RIF) after IVF remains a challenging topic for fertility specialists and a frustrating reality for patients with infertility. Various approaches have been investigated and applied towards the improvement of clinical outcomes. Through a nonrandomized clinical trial, we evaluated the effect of the combination of hysteroscopic endometrial injury and the freeze-all technique on pregnancy parameters in a cohort of RIF patients; (2) Methods: The study group comprised of 30 patients with RIF that underwent a hysteroscopic endometrial injury prior to a frozen embryo transfer cycle; another 30 patients with RIF, comprising the control group, underwent a standard frozen cycle with no adjuvant treatment before. Live birth comprised the primary outcome. Logistic and Poisson regression analyses were implemented to reveal potential independent predictors for all outcomes. (3) Results: Live birth rates were similar between groups (8/30 vs. 3/30, p = 0.0876). Biochemical and clinical pregnancy and miscarriages were also independent of the procedure (p = 0.7812, p = 0.3436 and p = 0.1213, respectively). The only confounding factor that contributed to biochemical pregnancy was the number of retrieved oocytes (0.1618 ± 0.0819, p = 0.0481); (4) Conclusions: The addition of endometrial injury to the freeze-all strategy in infertile women with RIF does not significantly improve pregnancy rates, including live birth. A properly conducted RCT with adequate sample size could give a robust answer. MDPI 2021-05-17 /pmc/articles/PMC8156614/ /pubmed/34067637 http://dx.doi.org/10.3390/jcm10102162 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rigos, Ioannis
Athanasiou, Vasileios
Vlahos, Nikolaos
Papantoniou, Nikolaos
Profer, Dimitrios
Siristatidis, Charalampos
The Addition of Endometrial Injury to Freeze-All Strategy in Women with Repeated Implantation Failures
title The Addition of Endometrial Injury to Freeze-All Strategy in Women with Repeated Implantation Failures
title_full The Addition of Endometrial Injury to Freeze-All Strategy in Women with Repeated Implantation Failures
title_fullStr The Addition of Endometrial Injury to Freeze-All Strategy in Women with Repeated Implantation Failures
title_full_unstemmed The Addition of Endometrial Injury to Freeze-All Strategy in Women with Repeated Implantation Failures
title_short The Addition of Endometrial Injury to Freeze-All Strategy in Women with Repeated Implantation Failures
title_sort addition of endometrial injury to freeze-all strategy in women with repeated implantation failures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156614/
https://www.ncbi.nlm.nih.gov/pubmed/34067637
http://dx.doi.org/10.3390/jcm10102162
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