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Fish Oil Increases Diet-Induced Thermogenesis in Mice
Increasing energy expenditure (EE) is beneficial for preventing obesity. Diet-induced thermogenesis (DIT) is one of the components of total EE. Therefore, increasing DIT is effective against obesity. We examined how much fish oil (FO) increased DIT by measuring absolute values of DIT in mice. C57BL/...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156710/ https://www.ncbi.nlm.nih.gov/pubmed/34067796 http://dx.doi.org/10.3390/md19050278 |
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author | Yamazaki, Tomomi Li, Dongyang Ikaga, Reina |
author_facet | Yamazaki, Tomomi Li, Dongyang Ikaga, Reina |
author_sort | Yamazaki, Tomomi |
collection | PubMed |
description | Increasing energy expenditure (EE) is beneficial for preventing obesity. Diet-induced thermogenesis (DIT) is one of the components of total EE. Therefore, increasing DIT is effective against obesity. We examined how much fish oil (FO) increased DIT by measuring absolute values of DIT in mice. C57BL/6J male mice were given diets of 30 energy% fat consisting of FO or safflower oil plus butter as control oil (Con). After administration for 9 days, respiration in mice was monitored, and then the data were used to calculate DIT and EE. DIT increased significantly by 1.2-fold in the FO-fed mice compared with the Con-fed mice. Body weight gain was significantly lower in the FO-fed mice. FO increased the levels of uncoupling protein 1 (Ucp1) mRNA and UCP1 protein in brown adipose tissue (BAT) by 1.5- and 1.2-fold, respectively. In subcutaneous white adipose tissue (subWAT), the levels of Ucp1 mRNA and UCP1 protein were increased by 6.3- and 2.7-fold, respectively, by FO administration. FO also significantly increased the expression of markers of browning in subWAT such as fibroblast growth factor 21 and cell death-inducing DNA fragmentation factor α-like effector a. Thus, dietary FO seems to increase DIT in mice via the increased expressions of Ucp1 in BAT and induced browning of subWAT. FO might be a promising dietary fat in the prevention of obesity by upregulation of energy metabolism. |
format | Online Article Text |
id | pubmed-8156710 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81567102021-05-28 Fish Oil Increases Diet-Induced Thermogenesis in Mice Yamazaki, Tomomi Li, Dongyang Ikaga, Reina Mar Drugs Article Increasing energy expenditure (EE) is beneficial for preventing obesity. Diet-induced thermogenesis (DIT) is one of the components of total EE. Therefore, increasing DIT is effective against obesity. We examined how much fish oil (FO) increased DIT by measuring absolute values of DIT in mice. C57BL/6J male mice were given diets of 30 energy% fat consisting of FO or safflower oil plus butter as control oil (Con). After administration for 9 days, respiration in mice was monitored, and then the data were used to calculate DIT and EE. DIT increased significantly by 1.2-fold in the FO-fed mice compared with the Con-fed mice. Body weight gain was significantly lower in the FO-fed mice. FO increased the levels of uncoupling protein 1 (Ucp1) mRNA and UCP1 protein in brown adipose tissue (BAT) by 1.5- and 1.2-fold, respectively. In subcutaneous white adipose tissue (subWAT), the levels of Ucp1 mRNA and UCP1 protein were increased by 6.3- and 2.7-fold, respectively, by FO administration. FO also significantly increased the expression of markers of browning in subWAT such as fibroblast growth factor 21 and cell death-inducing DNA fragmentation factor α-like effector a. Thus, dietary FO seems to increase DIT in mice via the increased expressions of Ucp1 in BAT and induced browning of subWAT. FO might be a promising dietary fat in the prevention of obesity by upregulation of energy metabolism. MDPI 2021-05-17 /pmc/articles/PMC8156710/ /pubmed/34067796 http://dx.doi.org/10.3390/md19050278 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yamazaki, Tomomi Li, Dongyang Ikaga, Reina Fish Oil Increases Diet-Induced Thermogenesis in Mice |
title | Fish Oil Increases Diet-Induced Thermogenesis in Mice |
title_full | Fish Oil Increases Diet-Induced Thermogenesis in Mice |
title_fullStr | Fish Oil Increases Diet-Induced Thermogenesis in Mice |
title_full_unstemmed | Fish Oil Increases Diet-Induced Thermogenesis in Mice |
title_short | Fish Oil Increases Diet-Induced Thermogenesis in Mice |
title_sort | fish oil increases diet-induced thermogenesis in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156710/ https://www.ncbi.nlm.nih.gov/pubmed/34067796 http://dx.doi.org/10.3390/md19050278 |
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