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Glutamatergic Mechanisms in Glioblastoma and Tumor-Associated Epilepsy
The progression of glioblastomas is associated with a variety of neurological impairments, such as tumor-related epileptic seizures. Seizures are not only a common comorbidity of glioblastoma but often an initial clinical symptom of this cancer entity. Both, glioblastoma and tumor-associated epileps...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156732/ https://www.ncbi.nlm.nih.gov/pubmed/34067762 http://dx.doi.org/10.3390/cells10051226 |
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author | Lange, Falko Hörnschemeyer, Julia Kirschstein, Timo |
author_facet | Lange, Falko Hörnschemeyer, Julia Kirschstein, Timo |
author_sort | Lange, Falko |
collection | PubMed |
description | The progression of glioblastomas is associated with a variety of neurological impairments, such as tumor-related epileptic seizures. Seizures are not only a common comorbidity of glioblastoma but often an initial clinical symptom of this cancer entity. Both, glioblastoma and tumor-associated epilepsy are closely linked to one another through several pathophysiological mechanisms, with the neurotransmitter glutamate playing a key role. Glutamate interacts with its ionotropic and metabotropic receptors to promote both tumor progression and excitotoxicity. In this review, based on its physiological functions, our current understanding of glutamate receptors and glutamatergic signaling will be discussed in detail. Furthermore, preclinical models to study glutamatergic interactions between glioma cells and the tumor-surrounding microenvironment will be presented. Finally, current studies addressing glutamate receptors in glioma and tumor-related epilepsy will be highlighted and future approaches to interfere with the glutamatergic network are discussed. |
format | Online Article Text |
id | pubmed-8156732 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81567322021-05-28 Glutamatergic Mechanisms in Glioblastoma and Tumor-Associated Epilepsy Lange, Falko Hörnschemeyer, Julia Kirschstein, Timo Cells Review The progression of glioblastomas is associated with a variety of neurological impairments, such as tumor-related epileptic seizures. Seizures are not only a common comorbidity of glioblastoma but often an initial clinical symptom of this cancer entity. Both, glioblastoma and tumor-associated epilepsy are closely linked to one another through several pathophysiological mechanisms, with the neurotransmitter glutamate playing a key role. Glutamate interacts with its ionotropic and metabotropic receptors to promote both tumor progression and excitotoxicity. In this review, based on its physiological functions, our current understanding of glutamate receptors and glutamatergic signaling will be discussed in detail. Furthermore, preclinical models to study glutamatergic interactions between glioma cells and the tumor-surrounding microenvironment will be presented. Finally, current studies addressing glutamate receptors in glioma and tumor-related epilepsy will be highlighted and future approaches to interfere with the glutamatergic network are discussed. MDPI 2021-05-17 /pmc/articles/PMC8156732/ /pubmed/34067762 http://dx.doi.org/10.3390/cells10051226 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lange, Falko Hörnschemeyer, Julia Kirschstein, Timo Glutamatergic Mechanisms in Glioblastoma and Tumor-Associated Epilepsy |
title | Glutamatergic Mechanisms in Glioblastoma and Tumor-Associated Epilepsy |
title_full | Glutamatergic Mechanisms in Glioblastoma and Tumor-Associated Epilepsy |
title_fullStr | Glutamatergic Mechanisms in Glioblastoma and Tumor-Associated Epilepsy |
title_full_unstemmed | Glutamatergic Mechanisms in Glioblastoma and Tumor-Associated Epilepsy |
title_short | Glutamatergic Mechanisms in Glioblastoma and Tumor-Associated Epilepsy |
title_sort | glutamatergic mechanisms in glioblastoma and tumor-associated epilepsy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156732/ https://www.ncbi.nlm.nih.gov/pubmed/34067762 http://dx.doi.org/10.3390/cells10051226 |
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