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Aldo-Keto Reductase 1C3 Mediates Chemotherapy Resistance in Esophageal Adenocarcinoma via ROS Detoxification

SIMPLE SUMMARY: The multidrug resistance of EAC is one of the major obstacles to chemotherapeutic efficiency. Our study aims to explore the molecular mechanism of AKR1C3 as a novel therapeutic target to overcome chemotherapy resistance for EAC patients. We demonstrate that AKR1C3 renders chemotherap...

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Detalles Bibliográficos
Autores principales:	Zhou, Chenghui, Wang, Zhefang, Li, Jiahui, Wu, Xiaolin, Fan, Ningbo, Li, Dai, Liu, Fanyu, Plum, Patrick S., Hoppe, Sascha, Hillmer, Axel M., Quaas, Alexandar, Gebauer, Florian, Chon, Seung-Hun, Bruns, Christiane J., Zhao, Yue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156851/ https://www.ncbi.nlm.nih.gov/pubmed/34065695 http://dx.doi.org/10.3390/cancers13102403

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